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- NCIT_C114298 IAO_0000115 "The sodium salt form of cridanimod, a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Upon intramuscular administration, cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells. In addition, this agent is able to increase the production and release of interferon (IFN) alpha and beta. PR is often downregulated in endometrial cancer and makes it resistant to progestin-mediated hormone therapy." @default.
- NCIT_C114298 NCIT_A6 NCIT_C77948 @default.
- NCIT_C114298 NCIT_NHC0 "C114298" @default.
- NCIT_C114298 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114298 NCIT_P108 "Cridanimod Sodium" @default.
- NCIT_C114298 NCIT_P208 "CL472224" @default.
- NCIT_C114298 NCIT_P210 "58880-43-6" @default.
- NCIT_C114298 NCIT_P319 "54W868ROLR" @default.
- NCIT_C114298 NCIT_P322 "FDA" @default.
- NCIT_C114298 NCIT_P329 "758316" @default.
- NCIT_C114298 NCIT_P330 "758316" @default.
- NCIT_C114298 NCIT_P399 "758316" @default.
- NCIT_C114298 normalizedInformationContent "100" @default.
- NCIT_C114298 referenceCount "1" @default.
- NCIT_C114298 hasExactSynonym "CRIDANIMOD SODIUM" @default.
- NCIT_C114298 hasExactSynonym "Cridanimod Sodium" @default.
- NCIT_C114298 hasExactSynonym "Sodium 2-(9-Oxoacridin-10yl) Acetate" @default.
- NCIT_C114298 hasExactSynonym "Virexxa" @default.
- NCIT_C114298 inSubset NCIT_C176424 @default.
- NCIT_C114298 inSubset NCIT_C63923 @default.
- NCIT_C114298 type Class @default.
- NCIT_C114298 isDefinedBy ncit.owl @default.
- NCIT_C114298 label "Cridanimod Sodium" @default.
- NCIT_C114298 subClassOf NCIT_C114298 @default.
- NCIT_C114298 subClassOf NCIT_C1908 @default.
- NCIT_C114298 subClassOf NCIT_C1909 @default.
- NCIT_C114298 subClassOf NCIT_C2140 @default.
- NCIT_C114298 subClassOf NCIT_C308 @default.