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- NCIT_C114379 IAO_0000115 "A radioconjugate labeled with the positron-emitting radioisotope, copper Cu 64, and also composed of plerixafor, a bicyclam and hematopoietic stem cell-mobilizing agent that targets the chemokine receptor CXCR4, with tumor imaging potential using positron emission tomography (PET)/computed tomography (CT). Upon administration, the plerixafor moiety blocks the binding of stromal cell-derived factor-1alpha (SDF-1alpha or CXCL12) to the cellular receptor CXCR4. In turn, the CXCR4-expressing tumor cells can be visualized using PET/CT and the resulting images could be used to predict a tumor's response to certain treatments. The expression of CXCR4 on cancer cells has been correlated with increased tumor cell survival, tumor progression, and increased metastatic potential." @default.
- NCIT_C114379 NCIT_NHC0 "C114379" @default.
- NCIT_C114379 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114379 NCIT_P108 "Copper Cu 64 Plerixafor" @default.
- NCIT_C114379 NCIT_P208 "CL471810" @default.
- NCIT_C114379 NCIT_P329 "758399" @default.
- NCIT_C114379 NCIT_P330 "758399" @default.
- NCIT_C114379 NCIT_P399 "758399" @default.
- NCIT_C114379 normalizedInformationContent "100" @default.
- NCIT_C114379 referenceCount "1" @default.
- NCIT_C114379 hasExactSynonym "64-Cu-plerixafor" @default.
- NCIT_C114379 hasExactSynonym "Copper Cu 64 Plerixafor" @default.
- NCIT_C114379 inSubset NCIT_C176424 @default.
- NCIT_C114379 type Class @default.
- NCIT_C114379 isDefinedBy ncit.owl @default.
- NCIT_C114379 label "Copper Cu 64 Plerixafor" @default.
- NCIT_C114379 subClassOf NCIT_C114379 @default.
- NCIT_C114379 subClassOf NCIT_C1446 @default.
- NCIT_C114379 subClassOf NCIT_C1908 @default.
- NCIT_C114379 subClassOf NCIT_C1909 @default.
- NCIT_C114379 subClassOf NCIT_C2124 @default.