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- NCIT_C114383 IAO_0000115 "An orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG-120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH1-expressing tumor cells. IDH1, an enzyme in the citric acid cycle, is mutated in a variety of cancers; it initiates and drives cancer growth by both blocking cell differentiation and catalyzing the formation of 2HG." @default.
- NCIT_C114383 NCIT_A32 NCIT_C1909 @default.
- NCIT_C114383 NCIT_A7 NCIT_C77217 @default.
- NCIT_C114383 NCIT_NHC0 "C114383" @default.
- NCIT_C114383 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114383 NCIT_P107 "Ivosidenib" @default.
- NCIT_C114383 NCIT_P108 "Ivosidenib" @default.
- NCIT_C114383 NCIT_P208 "CL471818" @default.
- NCIT_C114383 NCIT_P210 "1448347-49-6" @default.
- NCIT_C114383 NCIT_P302 "newly-diagnosed acute myeloid leukemia (AML) with a susceptible IDH1 mutation" @default.
- NCIT_C114383 NCIT_P319 "Q2PCN8MAM6" @default.
- NCIT_C114383 NCIT_P322 "CTRP" @default.
- NCIT_C114383 NCIT_P322 "FDA" @default.
- NCIT_C114383 NCIT_P322 "GDC" @default.
- NCIT_C114383 NCIT_P329 "758551" @default.
- NCIT_C114383 NCIT_P330 "758551" @default.
- NCIT_C114383 NCIT_P375 "Ivosidenib" @default.
- NCIT_C114383 NCIT_P399 "758551" @default.
- NCIT_C114383 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C114383 referenceCount "3" @default.
- NCIT_C114383 hasExactSynonym "AG-120" @default.
- NCIT_C114383 hasExactSynonym "IVOSIDENIB" @default.
- NCIT_C114383 hasExactSynonym "Ivosidenib" @default.
- NCIT_C114383 hasExactSynonym "Tibsovo" @default.
- NCIT_C114383 inSubset NCIT_C116977 @default.
- NCIT_C114383 inSubset NCIT_C116978 @default.
- NCIT_C114383 inSubset NCIT_C128784 @default.
- NCIT_C114383 inSubset NCIT_C157711 @default.
- NCIT_C114383 inSubset NCIT_C157712 @default.
- NCIT_C114383 inSubset NCIT_C176424 @default.
- NCIT_C114383 inSubset NCIT_C177537 @default.
- NCIT_C114383 inSubset NCIT_C63923 @default.
- NCIT_C114383 type Class @default.
- NCIT_C114383 isDefinedBy ncit.owl @default.
- NCIT_C114383 label "Ivosidenib" @default.
- NCIT_C114383 subClassOf NCIT_C114383 @default.
- NCIT_C114383 subClassOf NCIT_C129824 @default.
- NCIT_C114383 subClassOf NCIT_C129825 @default.
- NCIT_C114383 subClassOf NCIT_C137826 @default.
- NCIT_C114383 subClassOf NCIT_C163758 @default.
- NCIT_C114383 subClassOf NCIT_C168618 @default.
- NCIT_C114383 subClassOf NCIT_C1908 @default.
- NCIT_C114383 subClassOf NCIT_C1909 @default.
- NCIT_C114383 subClassOf NCIT_C2189 @default.
- NCIT_C114383 subClassOf NCIT_C274 @default.
- NCIT_C114383 subClassOf NCIT_C471 @default.