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- NCIT_C114384 IAO_0000115 "An orally bioavailable, selective small molecule B-cell lymphoma 2 (Bcl-2) Homology 3 (BH3) mimetic, with potential pro-apoptotic and antineoplastic activities. ABT-737 binds to the hydrophobic groove of multiple members of the anti-apoptotic Bcl-2 protein family, including Bcl-2, Bcl-xl and Bcl-w. This inhibits the activity of these pro-survival proteins and restores apoptotic processes in tumor cells, via activation of Bak/Bax-mediated apoptosis. The pro-survival Bcl-2 proteins are overexpressed in many cancers and play important roles in the regulation of apoptosis. Their expression is associated with increased drug resistance and tumor cell survival. ABT-737 does not inhibit the pro-survival proteins Mcl-1, Bcl-B, Bfl-1 (A1); therefore, tumors that overexpress these Bcl-2 family proteins are resistant to ABT-737." @default.
- NCIT_C114384 NCIT_A32 NCIT_C1909 @default.
- NCIT_C114384 NCIT_NHC0 "C114384" @default.
- NCIT_C114384 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114384 NCIT_P108 "BH3 Mimetic ABT-737" @default.
- NCIT_C114384 NCIT_P207 "C1570187" @default.
- NCIT_C114384 NCIT_P210 "852808-04-9" @default.
- NCIT_C114384 NCIT_P319 "Z5NFR173NV" @default.
- NCIT_C114384 NCIT_P322 "FDA" @default.
- NCIT_C114384 NCIT_P322 "GDC" @default.
- NCIT_C114384 NCIT_P329 "758552" @default.
- NCIT_C114384 NCIT_P330 "758552" @default.
- NCIT_C114384 NCIT_P375 "BH3 Mimetic ABT-737" @default.
- NCIT_C114384 NCIT_P399 "758552" @default.
- NCIT_C114384 normalizedInformationContent "100" @default.
- NCIT_C114384 referenceCount "1" @default.
- NCIT_C114384 hasExactSynonym "ABT-737" @default.
- NCIT_C114384 hasExactSynonym "BH3 Mimetic ABT-737" @default.
- NCIT_C114384 hasExactSynonym "Benzamide, 4-(4-((4'-Chloro(1,1'-biphenyl)-2-yl)methyl)-1-piperazinyl)-n-((4-(((1r)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)-" @default.
- NCIT_C114384 inSubset NCIT_C128784 @default.
- NCIT_C114384 inSubset NCIT_C157711 @default.
- NCIT_C114384 inSubset NCIT_C157712 @default.
- NCIT_C114384 inSubset NCIT_C176424 @default.
- NCIT_C114384 inSubset NCIT_C177537 @default.
- NCIT_C114384 inSubset NCIT_C63923 @default.
- NCIT_C114384 type Class @default.
- NCIT_C114384 isDefinedBy ncit.owl @default.
- NCIT_C114384 label "BH3 Mimetic ABT-737" @default.
- NCIT_C114384 subClassOf NCIT_C114384 @default.
- NCIT_C114384 subClassOf NCIT_C129839 @default.
- NCIT_C114384 subClassOf NCIT_C1908 @default.
- NCIT_C114384 subClassOf NCIT_C1909 @default.
- NCIT_C114384 subClassOf NCIT_C274 @default.