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- NCIT_C1144 IAO_0000115 "The acetate salt form of nafarelin, a modified synthetic porcine luteinizing hormone (LH)-releasing hormone peptide analog, with gonadotropin-releasing hormone (GnRH) agonist activity. Upon nasal inhalation, nafarelin acetate binds to the GnRH receptor. This initially results in the release of the gonadotropins, follicle-stimulating hormone (FSH) and LH, from the pituitary gland; however, prolonged stimulation of the GnRH receptor desensitizes the receptor, which leads to decreased secretion of FSH and LH. In females, the inhibition of gonadotropin secretion causes hypogonadotropic hypogonadism leading to decreased production of estrogen and progesterone and anovulation. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen following castration." @default.
- NCIT_C1144 NCIT_A6 NCIT_C61613 @default.
- NCIT_C1144 NCIT_NHC0 "C1144" @default.
- NCIT_C1144 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1144 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1144 NCIT_P108 "Nafarelin Acetate" @default.
- NCIT_C1144 NCIT_P207 "C0733433" @default.
- NCIT_C1144 NCIT_P210 "76932-60-0" @default.
- NCIT_C1144 NCIT_P210 "86220-42-0" @default.
- NCIT_C1144 NCIT_P319 "8ENZ0QJW4H" @default.
- NCIT_C1144 NCIT_P322 "FDA" @default.
- NCIT_C1144 NCIT_P350 "C66H83N17O13.C2H4O2.H2O" @default.
- NCIT_C1144 NCIT_P366 "Nafarelin" @default.
- NCIT_C1144 normalizedInformationContent "100" @default.
- NCIT_C1144 referenceCount "1" @default.
- NCIT_C1144 hasExactSynonym "(6-D-(2-Naphthyl)alanine)LHRH Acetate" @default.
- NCIT_C1144 hasExactSynonym "NAFARELIN ACETATE" @default.
- NCIT_C1144 hasExactSynonym "Nafarelin Acetate" @default.
- NCIT_C1144 hasExactSynonym "RS-94991298" @default.
- NCIT_C1144 hasExactSynonym "Synarel" @default.
- NCIT_C1144 hasExactSynonym "Synarela" @default.
- NCIT_C1144 hasExactSynonym "Synrelina" @default.
- NCIT_C1144 inSubset NCIT_C63923 @default.
- NCIT_C1144 type Class @default.
- NCIT_C1144 isDefinedBy ncit.owl @default.
- NCIT_C1144 label "Nafarelin Acetate" @default.
- NCIT_C1144 subClassOf NCIT_C1144 @default.
- NCIT_C1144 subClassOf NCIT_C147908 @default.
- NCIT_C1144 subClassOf NCIT_C1908 @default.
- NCIT_C1144 subClassOf NCIT_C1909 @default.
- NCIT_C1144 subClassOf NCIT_C1910 @default.
- NCIT_C1144 subClassOf NCIT_C548 @default.