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- NCIT_C114469 IAO_0000115 "A metabolite formed during the catabolism of estrone by the liver through the hydroxylation of the carbon at position 4 by cytochrome P450 (CYP) family enzymes, with potential carcinogenic activity. The mechanism of action for the tumor promoting activity of 4-hydroxyestrone is not known but this metabolic product has increased estrogenic activity compared to the parent compound. Additionally, oxidation of 4-hydroxyestrone generates compounds with free radicals that are capable of removing purines from DNA, which can cause mutagenesis and can lead to tumorigenesis." @default.
- NCIT_C114469 NCIT_NHC0 "C114469" @default.
- NCIT_C114469 NCIT_P106 "Organic Chemical" @default.
- NCIT_C114469 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114469 NCIT_P107 "4-Hydroxyestrone" @default.
- NCIT_C114469 NCIT_P108 "4-Hydroxyestrone" @default.
- NCIT_C114469 NCIT_P207 "C0048342" @default.
- NCIT_C114469 NCIT_P210 "3131-23-5" @default.
- NCIT_C114469 NCIT_P319 "3MN57C55S2" @default.
- NCIT_C114469 NCIT_P322 "CTRP" @default.
- NCIT_C114469 NCIT_P322 "FDA" @default.
- NCIT_C114469 normalizedInformationContent "100" @default.
- NCIT_C114469 referenceCount "1" @default.
- NCIT_C114469 hasExactSynonym "3,4-Dihydroxyestra-1,3,5(10)-trien-17-one" @default.
- NCIT_C114469 hasExactSynonym "4-HYDROXYESTRONE" @default.
- NCIT_C114469 hasExactSynonym "4-Hydroxyestrone" @default.
- NCIT_C114469 hasExactSynonym "4-OHE(1)" @default.
- NCIT_C114469 hasExactSynonym "4-OHE1" @default.
- NCIT_C114469 hasExactSynonym "Estra-1,3,5(10)-trien-17-one, 3,4-dihydroxy-" @default.
- NCIT_C114469 inSubset NCIT_C116977 @default.
- NCIT_C114469 inSubset NCIT_C142799 @default.
- NCIT_C114469 inSubset NCIT_C63923 @default.
- NCIT_C114469 type Class @default.
- NCIT_C114469 isDefinedBy ncit.owl @default.
- NCIT_C114469 label "4-Hydroxyestrone" @default.
- NCIT_C114469 subClassOf NCIT_C114469 @default.
- NCIT_C114469 subClassOf NCIT_C147908 @default.
- NCIT_C114469 subClassOf NCIT_C1636 @default.
- NCIT_C114469 subClassOf NCIT_C1908 @default.
- NCIT_C114469 subClassOf NCIT_C1909 @default.
- NCIT_C114469 subClassOf NCIT_C2181 @default.
- NCIT_C114469 subClassOf NCIT_C483 @default.
- NCIT_C114469 subClassOf NCIT_C548 @default.