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- NCIT_C114498 IAO_0000115 "An orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively binds to and blocks the GnRH receptor in the anterior pituitary gland, which both prevents GnRH binding to the GnRH receptor and inhibits the secretion and release of both luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone from Leydig cells in the testes. Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation." @default.
- NCIT_C114498 NCIT_A32 NCIT_C1909 @default.
- NCIT_C114498 NCIT_A7 NCIT_C38910 @default.
- NCIT_C114498 NCIT_NHC0 "C114498" @default.
- NCIT_C114498 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114498 NCIT_P107 "Relugolix" @default.
- NCIT_C114498 NCIT_P108 "Relugolix" @default.
- NCIT_C114498 NCIT_P207 "C3252109" @default.
- NCIT_C114498 NCIT_P210 "737789-87-6" @default.
- NCIT_C114498 NCIT_P302 "adult patients with advanced prostate cancer." @default.
- NCIT_C114498 NCIT_P319 "P76B05O5V6" @default.
- NCIT_C114498 NCIT_P322 "CTRP" @default.
- NCIT_C114498 NCIT_P322 "FDA" @default.
- NCIT_C114498 NCIT_P322 "GDC" @default.
- NCIT_C114498 NCIT_P322 "OORO" @default.
- NCIT_C114498 NCIT_P329 "759257" @default.
- NCIT_C114498 NCIT_P330 "759257" @default.
- NCIT_C114498 NCIT_P375 "Relugolix" @default.
- NCIT_C114498 NCIT_P399 "759257" @default.
- NCIT_C114498 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C114498 referenceCount "2" @default.
- NCIT_C114498 hasExactSynonym "N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea" @default.
- NCIT_C114498 hasExactSynonym "Orgovyx" @default.
- NCIT_C114498 hasExactSynonym "RELUGOLIX" @default.
- NCIT_C114498 hasExactSynonym "Relugolix" @default.
- NCIT_C114498 hasExactSynonym "Relumina" @default.
- NCIT_C114498 hasExactSynonym "TAK 385" @default.
- NCIT_C114498 hasExactSynonym "TAK-385" @default.
- NCIT_C114498 hasExactSynonym "Urea, N-(4-(1-((2,6-difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxy-" @default.
- NCIT_C114498 inSubset NCIT_C116977 @default.
- NCIT_C114498 inSubset NCIT_C116978 @default.
- NCIT_C114498 inSubset NCIT_C128784 @default.
- NCIT_C114498 inSubset NCIT_C157711 @default.
- NCIT_C114498 inSubset NCIT_C157712 @default.
- NCIT_C114498 inSubset NCIT_C176424 @default.
- NCIT_C114498 inSubset NCIT_C177537 @default.
- NCIT_C114498 inSubset NCIT_C192234 @default.
- NCIT_C114498 inSubset NCIT_C63923 @default.
- NCIT_C114498 type Class @default.
- NCIT_C114498 isDefinedBy ncit.owl @default.
- NCIT_C114498 label "Relugolix" @default.
- NCIT_C114498 subClassOf NCIT_C114498 @default.
- NCIT_C114498 subClassOf NCIT_C147908 @default.
- NCIT_C114498 subClassOf NCIT_C1908 @default.
- NCIT_C114498 subClassOf NCIT_C1909 @default.
- NCIT_C114498 subClassOf NCIT_C2092 @default.
- NCIT_C114498 subClassOf NCIT_C547 @default.