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- NCIT_C114499 IAO_0000115 "A radioconjugate composed of PP-F11N, a gastrin analog, conjugated to the beta-emitting radioisotope lutetium Lu 177, with potential antineoplastic activity and potential use as an imaging agent for scintigraphy. Following intravenous administration, the PP-F11N moiety binds to the cholecystokinin-2 (CCK-2) receptor. Subsequently, the CCK-2 receptor-expressing tumor cells can be visualized scintigraphically. In addition, the radioisotope moiety delivers a cytotoxic dose of beta radiation to CCK-2 receptor-expressing tumor cells. CCK-2 receptors are expressed on a variety of tumor cell types." @default.
- NCIT_C114499 NCIT_A32 NCIT_C1909 @default.
- NCIT_C114499 NCIT_NHC0 "C114499" @default.
- NCIT_C114499 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114499 NCIT_P108 "Lutetium Lu 177 PP-F11N" @default.
- NCIT_C114499 NCIT_P208 "CL472324" @default.
- NCIT_C114499 NCIT_P210 "1771736-69-6" @default.
- NCIT_C114499 NCIT_P319 "639NVQ0SXF" @default.
- NCIT_C114499 NCIT_P322 "FDA" @default.
- NCIT_C114499 NCIT_P322 "GDC" @default.
- NCIT_C114499 NCIT_P329 "759373" @default.
- NCIT_C114499 NCIT_P330 "759373" @default.
- NCIT_C114499 NCIT_P375 "Lutetium Lu 177 PP-F11N" @default.
- NCIT_C114499 NCIT_P399 "759373" @default.
- NCIT_C114499 normalizedInformationContent "100" @default.
- NCIT_C114499 referenceCount "1" @default.
- NCIT_C114499 hasExactSynonym "177Lu-PP-F11N" @default.
- NCIT_C114499 hasExactSynonym "Lutetium Lu 177 PP-F11N" @default.
- NCIT_C114499 hasExactSynonym "PP-F11N LUTETIUM LU-177" @default.
- NCIT_C114499 inSubset NCIT_C128784 @default.
- NCIT_C114499 inSubset NCIT_C157711 @default.
- NCIT_C114499 inSubset NCIT_C157712 @default.
- NCIT_C114499 inSubset NCIT_C176424 @default.
- NCIT_C114499 inSubset NCIT_C177537 @default.
- NCIT_C114499 inSubset NCIT_C63923 @default.
- NCIT_C114499 type Class @default.
- NCIT_C114499 isDefinedBy ncit.owl @default.
- NCIT_C114499 label "Lutetium Lu 177 PP-F11N" @default.
- NCIT_C114499 subClassOf NCIT_C114499 @default.
- NCIT_C114499 subClassOf NCIT_C129819 @default.
- NCIT_C114499 subClassOf NCIT_C1446 @default.
- NCIT_C114499 subClassOf NCIT_C1908 @default.
- NCIT_C114499 subClassOf NCIT_C1909 @default.
- NCIT_C114499 subClassOf NCIT_C2124 @default.
- NCIT_C114499 subClassOf NCIT_C274 @default.