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- NCIT_C114501 IAO_0000115 "A radioconjugate composed of an affinity-matured antibody fragment, the A11 minibody, directed against human prostate stem cell antigen (PSCA), and conjugated with the radioisotope iodine I 124, that can potentially be used as an imaging agent for positron emission tomography (PET)/computed tomography (CT). The minibody moiety of iodine I 124-labeled anti-PSCA A11 minibody selectively targets and binds to PSCA. The PSCA-expressing tumor cells can then be visualized using PET/CT. PSCA, a cell surface antigen expressed in normal human prostate and bladder, is overexpressed in a variety of cancers, including bladder, pancreatic, and prostate cancer. The A11 minibody is formed by the fusion of a single chain Fv fragment with the immunoglobulin G1 CH3 domain." @default.
- NCIT_C114501 NCIT_A7 NCIT_C50887 @default.
- NCIT_C114501 NCIT_NHC0 "C114501" @default.
- NCIT_C114501 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C114501 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C114501 NCIT_P107 "Iodine I 124-labeled Anti-PSCA A11 Minibody" @default.
- NCIT_C114501 NCIT_P108 "Iodine I 124-labeled Anti-PSCA A11 Minibody" @default.
- NCIT_C114501 NCIT_P208 "CL472326" @default.
- NCIT_C114501 NCIT_P322 "CTRP" @default.
- NCIT_C114501 NCIT_P329 "759449" @default.
- NCIT_C114501 NCIT_P330 "759449" @default.
- NCIT_C114501 NCIT_P399 "759449" @default.
- NCIT_C114501 normalizedInformationContent "100" @default.
- NCIT_C114501 referenceCount "1" @default.
- NCIT_C114501 hasExactSynonym "124I-A11 PSCA Minibody" @default.
- NCIT_C114501 hasExactSynonym "Iodine I 124-labeled Anti-PSCA A11 Minibody" @default.
- NCIT_C114501 inSubset NCIT_C116977 @default.
- NCIT_C114501 inSubset NCIT_C116978 @default.
- NCIT_C114501 inSubset NCIT_C176424 @default.
- NCIT_C114501 type Class @default.
- NCIT_C114501 isDefinedBy ncit.owl @default.
- NCIT_C114501 label "Iodine I 124-labeled Anti-PSCA A11 Minibody" @default.
- NCIT_C114501 subClassOf NCIT_C114501 @default.
- NCIT_C114501 subClassOf NCIT_C1446 @default.
- NCIT_C114501 subClassOf NCIT_C1511 @default.
- NCIT_C114501 subClassOf NCIT_C1512 @default.
- NCIT_C114501 subClassOf NCIT_C1908 @default.
- NCIT_C114501 subClassOf NCIT_C1909 @default.
- NCIT_C114501 subClassOf NCIT_C2124 @default.
- NCIT_C114501 subClassOf NCIT_C307 @default.
- NCIT_C114501 subClassOf NCIT_C308 @default.