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- NCIT_C114975 IAO_0000115 "An oligonucleotide targeted to the mRNA of MYD88 L265P, a mutant form of the linker protein MYD88, with potential antitumor activity. Bazlitoran binds to and inhibits the translation of mutated MYD88 L265P mRNA. This prevents overactivation of signaling pathways mediated by toll-like receptors (TLRs) 7, 8, and 9, nuclear factor-kappa B (NF-kB) activity, Janus-associated kinases-signal transducer and activator of transcription (JAK-STAT) signaling and the production of various cytokines. Together, this leads to an induction of apoptosis and an inhibition of tumor cell proliferation in MYD88 L265P-expressing tumor cells. MYD88, a key adaptor protein in the TLR signaling pathway, is mutated in a variety of B-cell lymphomas, including Waldenstrom's macroglobulinemia (WM) and activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL)." @default.
- NCIT_C114975 NCIT_A32 NCIT_C1909 @default.
- NCIT_C114975 NCIT_NHC0 "C114975" @default.
- NCIT_C114975 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C114975 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114975 NCIT_P108 "Bazlitoran" @default.
- NCIT_C114975 NCIT_P208 "CL472572" @default.
- NCIT_C114975 NCIT_P210 "1378549-07-5" @default.
- NCIT_C114975 NCIT_P319 "2U46M95B5M" @default.
- NCIT_C114975 NCIT_P322 "FDA" @default.
- NCIT_C114975 NCIT_P322 "GDC" @default.
- NCIT_C114975 NCIT_P329 "759500" @default.
- NCIT_C114975 NCIT_P330 "759500" @default.
- NCIT_C114975 NCIT_P375 "Bazlitoran" @default.
- NCIT_C114975 NCIT_P375 "TLR7/8/9 Antagonist IMO-8400" @default.
- NCIT_C114975 NCIT_P399 "759500" @default.
- NCIT_C114975 normalizedInformationContent "100" @default.
- NCIT_C114975 referenceCount "1" @default.
- NCIT_C114975 hasExactSynonym "BAZLITORAN" @default.
- NCIT_C114975 hasExactSynonym "Bazlitoran" @default.
- NCIT_C114975 hasExactSynonym "IMO-8400" @default.
- NCIT_C114975 hasExactSynonym "Oligonucleotide IMO-8400" @default.
- NCIT_C114975 inSubset NCIT_C128784 @default.
- NCIT_C114975 inSubset NCIT_C157711 @default.
- NCIT_C114975 inSubset NCIT_C157712 @default.
- NCIT_C114975 inSubset NCIT_C176424 @default.
- NCIT_C114975 inSubset NCIT_C177537 @default.
- NCIT_C114975 inSubset NCIT_C63923 @default.
- NCIT_C114975 type Class @default.
- NCIT_C114975 isDefinedBy ncit.owl @default.
- NCIT_C114975 label "Bazlitoran" @default.
- NCIT_C114975 subClassOf NCIT_C114975 @default.
- NCIT_C114975 subClassOf NCIT_C1291 @default.
- NCIT_C114975 subClassOf NCIT_C1908 @default.
- NCIT_C114975 subClassOf NCIT_C1909 @default.
- NCIT_C114975 subClassOf NCIT_C1962 @default.
- NCIT_C114975 subClassOf NCIT_C307 @default.