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- NCIT_C114981 IAO_0000115 "An orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Although the exact mechanism of action of daclatasvir has yet to be fully determined, this agent, upon oral administration and after intracellular uptake, appears to bind to domain I of the NS5A protein. This inhibits the activity of the NS5A protein and results in the disruption of the viral RNA replication complex, blockage of viral HCV RNA production, and inhibition of viral replication. NS5A, a zinc-binding and proline-rich hydrophilic phosphoprotein, plays a crucial role in HCV RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family." @default.
- NCIT_C114981 NCIT_NHC0 "C114981" @default.
- NCIT_C114981 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114981 NCIT_P108 "Daclatasvir" @default.
- NCIT_C114981 NCIT_P207 "C2933824" @default.
- NCIT_C114981 NCIT_P210 "1009119-64-5" @default.
- NCIT_C114981 NCIT_P319 "LI2427F9CI" @default.
- NCIT_C114981 NCIT_P322 "FDA" @default.
- NCIT_C114981 NCIT_P329 "759583" @default.
- NCIT_C114981 NCIT_P330 "759583" @default.
- NCIT_C114981 NCIT_P399 "759583" @default.
- NCIT_C114981 normalizedInformationContent "100" @default.
- NCIT_C114981 referenceCount "1" @default.
- NCIT_C114981 hasExactSynonym "BMS-790052" @default.
- NCIT_C114981 hasExactSynonym "Carbamic Acid, N,N'-((1,1'-biphenyl)-4,4'-diylbis(1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl((1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl)))bis-, C,C'-dimethyl Ester" @default.
- NCIT_C114981 hasExactSynonym "DACLATASVIR" @default.
- NCIT_C114981 hasExactSynonym "DCV" @default.
- NCIT_C114981 hasExactSynonym "Daclatasvir" @default.
- NCIT_C114981 inSubset NCIT_C173381 @default.
- NCIT_C114981 inSubset NCIT_C173383 @default.
- NCIT_C114981 inSubset NCIT_C176424 @default.
- NCIT_C114981 inSubset NCIT_C63923 @default.
- NCIT_C114981 type Class @default.
- NCIT_C114981 isDefinedBy ncit.owl @default.
- NCIT_C114981 label "Daclatasvir" @default.
- NCIT_C114981 subClassOf NCIT_C114981 @default.
- NCIT_C114981 subClassOf NCIT_C1908 @default.
- NCIT_C114981 subClassOf NCIT_C1909 @default.
- NCIT_C114981 subClassOf NCIT_C254 @default.
- NCIT_C114981 subClassOf NCIT_C281 @default.