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- NCIT_C114982 IAO_0000115 "An orally bioavailable inhibitor of the nonstructural protein 3 (NS3), with potential activity against hepatitis C virus (HCV). Upon administration, asunaprevir binds to the active center of the HCV NS3 and prevents NS3 protease-mediated polyprotein maturation. This disrupts the processing of viral proteins required for HCV replication. NS3, a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein and plays a key role during HCV viral RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family." @default.
- NCIT_C114982 NCIT_NHC0 "C114982" @default.
- NCIT_C114982 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114982 NCIT_P108 "Asunaprevir" @default.
- NCIT_C114982 NCIT_P207 "C3491974" @default.
- NCIT_C114982 NCIT_P210 "630420-16-5" @default.
- NCIT_C114982 NCIT_P319 "S9X0KRJ00S" @default.
- NCIT_C114982 NCIT_P322 "FDA" @default.
- NCIT_C114982 NCIT_P329 "759584" @default.
- NCIT_C114982 NCIT_P330 "759584" @default.
- NCIT_C114982 NCIT_P399 "759584" @default.
- NCIT_C114982 normalizedInformationContent "100" @default.
- NCIT_C114982 referenceCount "1" @default.
- NCIT_C114982 hasExactSynonym "1,1-Dimethylethyl ((1S)-1-(((2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2- (((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-ethenylcyclopropyl)carbamoyl) pyrrolidin-1-yl)carbonyl)-2,2-dimethylpropyl)carbamate" @default.
- NCIT_C114982 hasExactSynonym "ASUNAPREVIR" @default.
- NCIT_C114982 hasExactSynonym "ASV" @default.
- NCIT_C114982 hasExactSynonym "Asunaprevir" @default.
- NCIT_C114982 hasExactSynonym "BMS-650032" @default.
- NCIT_C114982 inSubset NCIT_C176424 @default.
- NCIT_C114982 inSubset NCIT_C63923 @default.
- NCIT_C114982 type Class @default.
- NCIT_C114982 isDefinedBy ncit.owl @default.
- NCIT_C114982 label "Asunaprevir" @default.
- NCIT_C114982 subClassOf NCIT_C114982 @default.
- NCIT_C114982 subClassOf NCIT_C1908 @default.
- NCIT_C114982 subClassOf NCIT_C1909 @default.
- NCIT_C114982 subClassOf NCIT_C471 @default.
- NCIT_C114982 subClassOf NCIT_C783 @default.