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- NCIT_C114983 IAO_0000115 "A non-nucleoside, polymerase inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B), a RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intracellular uptake, beclabuvir allosterically binds to the non-catalytic Thumb 1 site of viral HCV NS5B polymerase and causes a decrease in viral RNA synthesis and replication. The HCV NS5B protein is essential for the replication of the viral HCV RNA genome. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family." @default.
- NCIT_C114983 NCIT_NHC0 "C114983" @default.
- NCIT_C114983 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114983 NCIT_P108 "Beclabuvir" @default.
- NCIT_C114983 NCIT_P207 "C3852614" @default.
- NCIT_C114983 NCIT_P210 "958002-33-0" @default.
- NCIT_C114983 NCIT_P319 "MYW1X5CO9S" @default.
- NCIT_C114983 NCIT_P322 "FDA" @default.
- NCIT_C114983 NCIT_P329 "759585" @default.
- NCIT_C114983 NCIT_P330 "759585" @default.
- NCIT_C114983 NCIT_P399 "759585" @default.
- NCIT_C114983 normalizedInformationContent "100" @default.
- NCIT_C114983 referenceCount "1" @default.
- NCIT_C114983 hasExactSynonym "(4bS,5aR)-12-Cyclohexyl-N-(dimethylsulfamoyl)-3-methoxy-5a-((3-methyl-3,8-diazabicyclo(3.2.1)oct-8-yl)carbonyl)-4b,5,5a,6-tetrahydrocyclopropa(d)indolo(2,1-a)(2)benzazepine-9-carboxamide" @default.
- NCIT_C114983 hasExactSynonym "BECLABUVIR" @default.
- NCIT_C114983 hasExactSynonym "BMS-791325" @default.
- NCIT_C114983 hasExactSynonym "Beclabuvir" @default.
- NCIT_C114983 inSubset NCIT_C176424 @default.
- NCIT_C114983 inSubset NCIT_C63923 @default.
- NCIT_C114983 type Class @default.
- NCIT_C114983 isDefinedBy ncit.owl @default.
- NCIT_C114983 label "Beclabuvir" @default.
- NCIT_C114983 subClassOf NCIT_C114983 @default.
- NCIT_C114983 subClassOf NCIT_C1908 @default.
- NCIT_C114983 subClassOf NCIT_C1909 @default.
- NCIT_C114983 subClassOf NCIT_C471 @default.
- NCIT_C114983 subClassOf NCIT_C783 @default.