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- NCIT_C114984 IAO_0000115 "An orally bioavailable inhibitor of the tyrosine kinases tropomyosin receptor kinases (Trk) A, B and C, C-ros oncogene 1 (ROS1) and anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon administration, entrectinib binds to and inhibits TrkA, TrkB, TrkC, ROS1 and ALK. Inhibition of these kinases may result in a disruption of TrkA-, TrkB-, TrkC-, ROS1-, and ALK-mediated signaling. This leads to an induction of apoptosis and an inhibition of tumor cell proliferation in tumor cells that express these kinases. TrkA, TrkB, TrkC, ROS1 and ALK are overexpressed in a variety of cancer cell types." @default.
- NCIT_C114984 NCIT_A32 NCIT_C1909 @default.
- NCIT_C114984 NCIT_NHC0 "C114984" @default.
- NCIT_C114984 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C114984 NCIT_P108 "Entrectinib" @default.
- NCIT_C114984 NCIT_P207 "C3896774" @default.
- NCIT_C114984 NCIT_P210 "1108743-60-7" @default.
- NCIT_C114984 NCIT_P319 "L5ORF0AN1I" @default.
- NCIT_C114984 NCIT_P322 "FDA" @default.
- NCIT_C114984 NCIT_P322 "GDC" @default.
- NCIT_C114984 NCIT_P329 "759586" @default.
- NCIT_C114984 NCIT_P330 "759586" @default.
- NCIT_C114984 NCIT_P375 "Entrectinib" @default.
- NCIT_C114984 NCIT_P399 "759586" @default.
- NCIT_C114984 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C114984 referenceCount "2" @default.
- NCIT_C114984 hasExactSynonym "ENTRECTINIB" @default.
- NCIT_C114984 hasExactSynonym "Entrectinib" @default.
- NCIT_C114984 hasExactSynonym "N-(5-(3,5-Difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide" @default.
- NCIT_C114984 hasExactSynonym "RXDX 101" @default.
- NCIT_C114984 hasExactSynonym "RXDX-101" @default.
- NCIT_C114984 hasExactSynonym "RXDX101" @default.
- NCIT_C114984 hasExactSynonym "Rozlytrek" @default.
- NCIT_C114984 inSubset NCIT_C128784 @default.
- NCIT_C114984 inSubset NCIT_C157711 @default.
- NCIT_C114984 inSubset NCIT_C157712 @default.
- NCIT_C114984 inSubset NCIT_C176424 @default.
- NCIT_C114984 inSubset NCIT_C177537 @default.
- NCIT_C114984 inSubset NCIT_C63923 @default.
- NCIT_C114984 type Class @default.
- NCIT_C114984 isDefinedBy ncit.owl @default.
- NCIT_C114984 label "Entrectinib" @default.
- NCIT_C114984 subClassOf NCIT_C114984 @default.
- NCIT_C114984 subClassOf NCIT_C129824 @default.
- NCIT_C114984 subClassOf NCIT_C129825 @default.
- NCIT_C114984 subClassOf NCIT_C1404 @default.
- NCIT_C114984 subClassOf NCIT_C141136 @default.
- NCIT_C114984 subClassOf NCIT_C163758 @default.
- NCIT_C114984 subClassOf NCIT_C1908 @default.
- NCIT_C114984 subClassOf NCIT_C1909 @default.
- NCIT_C114984 subClassOf NCIT_C1967 @default.
- NCIT_C114984 subClassOf NCIT_C2189 @default.
- NCIT_C114984 subClassOf NCIT_C274 @default.
- NCIT_C114984 subClassOf NCIT_C471 @default.