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- NCIT_C115103 IAO_0000115 "An extract of the plant Dioscorea nipponica Makino and inhibitor of both the serine/threonine protein kinase Akt (protein kinase B) and members of the phosphatidylinositol 3-kinase (PI3K) family of lipid kinases, with potential antineoplastic and anti-metastatic activities. Dioscorea nipponica Makino extracted with ethyl acetate (DNE3) binds to and inhibits PI3K and Akt. This inhibits PI3K/Akt-mediated signaling and prevents both growth and survival of PI3K/Akt-overexpressing tumor cells. In addition, DNE3 increases the expression of tissue inhibitor of metalloproteinase-2 (TIMP-2), inhibits the secretion of matrix metalloproteinases (MMPs), primarily MMP-2 and MMP-9, and inhibits the serine protease urokinase (urokinase-type plasminogen activator; u-PA). This inhibits tumor cell invasion, migration, motility, and adhesion. This agent also inhibits the activation of both cAMP response element-binding (CREB) and activating protein-1 (AP-1), and increases the expression of IkappaB (IkB), which inhibits the activation of nuclear factor-kappa B (NF-kB). These processes further contribute to this agent's anti-tumor potential in susceptible tumor cells." @default.
- NCIT_C115103 NCIT_A32 NCIT_C1909 @default.
- NCIT_C115103 NCIT_NHC0 "C115103" @default.
- NCIT_C115103 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C115103 NCIT_P108 "Dioscorea nipponica Makino Extract DNE3" @default.
- NCIT_C115103 NCIT_P208 "CL472634" @default.
- NCIT_C115103 NCIT_P322 "GDC" @default.
- NCIT_C115103 NCIT_P329 "759832" @default.
- NCIT_C115103 NCIT_P330 "759832" @default.
- NCIT_C115103 NCIT_P375 "Dioscorea nipponica Makino Extract DNE3" @default.
- NCIT_C115103 NCIT_P399 "759832" @default.
- NCIT_C115103 normalizedInformationContent "100" @default.
- NCIT_C115103 referenceCount "1" @default.
- NCIT_C115103 hasExactSynonym "DNE3" @default.
- NCIT_C115103 hasExactSynonym "Dioscorea nipponica Extract with Ethyl Acetate" @default.
- NCIT_C115103 hasExactSynonym "Dioscorea nipponica Makino Extract DNE3" @default.
- NCIT_C115103 inSubset NCIT_C128784 @default.
- NCIT_C115103 inSubset NCIT_C157711 @default.
- NCIT_C115103 inSubset NCIT_C157712 @default.
- NCIT_C115103 inSubset NCIT_C176424 @default.
- NCIT_C115103 inSubset NCIT_C177537 @default.
- NCIT_C115103 type Class @default.
- NCIT_C115103 isDefinedBy ncit.owl @default.
- NCIT_C115103 label "Dioscorea nipponica Makino Extract DNE3" @default.
- NCIT_C115103 subClassOf NCIT_C115103 @default.
- NCIT_C115103 subClassOf NCIT_C1404 @default.
- NCIT_C115103 subClassOf NCIT_C1908 @default.
- NCIT_C115103 subClassOf NCIT_C1909 @default.
- NCIT_C115103 subClassOf NCIT_C471 @default.