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- NCIT_C115110 IAO_0000115 "An orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, ASP8273 covalently binds to and inhibits the activity of mutant forms of EGFR, including the T790M EGFR mutant, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. ASP8273 preferentially inhibits mutated forms of EGFR including T790M, a secondarily acquired resistance mutation, and may have therapeutic benefits in tumors with T790M-mediated resistance when compared to other EGFR tyrosine kinase inhibitors. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced as compared to non-selective EGFR inhibitors which also inhibit wild-type EGFR." @default.
- NCIT_C115110 NCIT_A32 NCIT_C1909 @default.
- NCIT_C115110 NCIT_NHC0 "C115110" @default.
- NCIT_C115110 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C115110 NCIT_P108 "Naquotinib" @default.
- NCIT_C115110 NCIT_P208 "CL472641" @default.
- NCIT_C115110 NCIT_P210 "1448232-80-1" @default.
- NCIT_C115110 NCIT_P319 "47DD4548PB" @default.
- NCIT_C115110 NCIT_P322 "FDA" @default.
- NCIT_C115110 NCIT_P322 "GDC" @default.
- NCIT_C115110 NCIT_P329 "760029" @default.
- NCIT_C115110 NCIT_P330 "760029" @default.
- NCIT_C115110 NCIT_P375 "Naquotinib" @default.
- NCIT_C115110 NCIT_P399 "760029" @default.
- NCIT_C115110 normalizedInformationContent "100" @default.
- NCIT_C115110 referenceCount "1" @default.
- NCIT_C115110 hasExactSynonym "2-Pyrazinecarboxamide, 6-Ethyl-3-((4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-(((3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl)oxy)-" @default.
- NCIT_C115110 hasExactSynonym "ASP8273" @default.
- NCIT_C115110 hasExactSynonym "NAQUOTINIB" @default.
- NCIT_C115110 hasExactSynonym "Naquotinib" @default.
- NCIT_C115110 inSubset NCIT_C128784 @default.
- NCIT_C115110 inSubset NCIT_C157711 @default.
- NCIT_C115110 inSubset NCIT_C157712 @default.
- NCIT_C115110 inSubset NCIT_C176424 @default.
- NCIT_C115110 inSubset NCIT_C177537 @default.
- NCIT_C115110 inSubset NCIT_C63923 @default.
- NCIT_C115110 type Class @default.
- NCIT_C115110 isDefinedBy ncit.owl @default.
- NCIT_C115110 label "Naquotinib" @default.
- NCIT_C115110 subClassOf NCIT_C115110 @default.
- NCIT_C115110 subClassOf NCIT_C129824 @default.
- NCIT_C115110 subClassOf NCIT_C129825 @default.
- NCIT_C115110 subClassOf NCIT_C1404 @default.
- NCIT_C115110 subClassOf NCIT_C163758 @default.
- NCIT_C115110 subClassOf NCIT_C163952 @default.
- NCIT_C115110 subClassOf NCIT_C1908 @default.
- NCIT_C115110 subClassOf NCIT_C1909 @default.
- NCIT_C115110 subClassOf NCIT_C1967 @default.
- NCIT_C115110 subClassOf NCIT_C2167 @default.
- NCIT_C115110 subClassOf NCIT_C2189 @default.
- NCIT_C115110 subClassOf NCIT_C274 @default.
- NCIT_C115110 subClassOf NCIT_C471 @default.