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- NCIT_C115959 IAO_0000115 "A synthetic CpG-rich oligonucleotide with potential immunopotentiating activity. TLR9 agonist DUK-CPG-001 binds to and activates intracellular toll-like receptor 9 (TLR9) in monocytes/macrophages, plasmacytoid dendritic cells (DCs), natural killer (NK) cells and B-cells. This initiates immune signaling pathways, activates DCs, NK cells and B-cells, and induces both the production of T-helper 1 cells (Th1) and a Th1-mediated immune response. TLR9 is a member of the TLR family, which plays a key role in both pathogen recognition and the activation of innate immunity." @default.
- NCIT_C115959 NCIT_A7 NCIT_C96048 @default.
- NCIT_C115959 NCIT_NHC0 "C115959" @default.
- NCIT_C115959 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C115959 NCIT_P107 "TLR9 Agonist DUK-CPG-001" @default.
- NCIT_C115959 NCIT_P108 "TLR9 Agonist DUK-CPG-001" @default.
- NCIT_C115959 NCIT_P208 "CL473296" @default.
- NCIT_C115959 NCIT_P322 "CTRP" @default.
- NCIT_C115959 NCIT_P329 "760142" @default.
- NCIT_C115959 NCIT_P330 "760142" @default.
- NCIT_C115959 NCIT_P399 "760142" @default.
- NCIT_C115959 normalizedInformationContent "100" @default.
- NCIT_C115959 referenceCount "1" @default.
- NCIT_C115959 hasExactSynonym "DUK-CPG-001" @default.
- NCIT_C115959 hasExactSynonym "TLR9 Agonist DUK-CPG-001" @default.
- NCIT_C115959 inSubset NCIT_C116977 @default.
- NCIT_C115959 inSubset NCIT_C116978 @default.
- NCIT_C115959 inSubset NCIT_C176424 @default.
- NCIT_C115959 type Class @default.
- NCIT_C115959 isDefinedBy ncit.owl @default.
- NCIT_C115959 label "TLR9 Agonist DUK-CPG-001" @default.
- NCIT_C115959 subClassOf NCIT_C115959 @default.
- NCIT_C115959 subClassOf NCIT_C177174 @default.
- NCIT_C115959 subClassOf NCIT_C177175 @default.
- NCIT_C115959 subClassOf NCIT_C1908 @default.
- NCIT_C115959 subClassOf NCIT_C1909 @default.
- NCIT_C115959 subClassOf NCIT_C2139 @default.
- NCIT_C115959 subClassOf NCIT_C308 @default.