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- NCIT_C115961 IAO_0000115 "A water-based, vaginal moisturizing gel containing a mixture of lambda- and kappa- carrageenans, sulfated polysaccharides derived from red seaweed (Chondrus crispus), with potential microbicidal activity against various viruses, including human papillomavirus (HPV), human immunodeficiencyvirus (HIV) and human herpes simplex virus (HSV). Upon vaginal insertion via an applicator, carrageenan specifically binds to the viral capsids, which prevents the binding of virions to heparan sulfate proteoglycan (HSPG) receptors or other, as of yet not fully identified, cellular proteins. In addition, the viral binding of carrageenan may also interfere with conformational changes within the virions after cellular attachment. This inhibits viral infection. Certain HPV types cause cervical cancer; therefore, the prevention of HPV infection by this gel may subsequently prevent the development of cervical cancer." @default.
- NCIT_C115961 NCIT_NHC0 "C115961" @default.
- NCIT_C115961 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C115961 NCIT_P108 "Carrageenan-containing Gel" @default.
- NCIT_C115961 NCIT_P208 "CL473298" @default.
- NCIT_C115961 NCIT_P329 "760314" @default.
- NCIT_C115961 NCIT_P330 "760314" @default.
- NCIT_C115961 NCIT_P399 "760314" @default.
- NCIT_C115961 normalizedInformationContent "100" @default.
- NCIT_C115961 referenceCount "1" @default.
- NCIT_C115961 hasExactSynonym "Carrageenan-containing Gel" @default.
- NCIT_C115961 hasExactSynonym "Divine 9 with Carragel" @default.
- NCIT_C115961 inSubset NCIT_C128784 @default.
- NCIT_C115961 inSubset NCIT_C176424 @default.
- NCIT_C115961 type Class @default.
- NCIT_C115961 isDefinedBy ncit.owl @default.
- NCIT_C115961 label "Carrageenan-containing Gel" @default.
- NCIT_C115961 subClassOf NCIT_C115961 @default.
- NCIT_C115961 subClassOf NCIT_C1908 @default.
- NCIT_C115961 subClassOf NCIT_C1909 @default.
- NCIT_C115961 subClassOf NCIT_C254 @default.