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- NCIT_C115969 IAO_0000115 "A preparation of autologous natural killer (NK) cells that are stimulated ex vivo by a 14-mer heat shock protein 70 (Hsp70) TKD peptide and interleukin-2 (IL-2), with potential tumor-selective cytolytic activity. Upon re-infusion into the patient, the treated NK cells recognize and bind to Hsp70-expressing tumor cells, which induces NK-mediated tumor cell lysis. Hsp70, a membrane-bound, stress-inducible protein, is overexpressed on almost all tumor cells; however, it is absent or minimally present on normal, healthy cells. TKD is the C-terminal substrate-binding domain of Hsp70 and is the structure recognized by the activated NK cells." @default.
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- NCIT_C115969 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C115969 NCIT_P108 "Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells" @default.
- NCIT_C115969 NCIT_P208 "CL473303" @default.
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- NCIT_C115969 hasExactSynonym "Hsp70-peptide TKD/IL-2-activated Autologous NK Cells" @default.
- NCIT_C115969 hasExactSynonym "Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells" @default.
- NCIT_C115969 inSubset NCIT_C128784 @default.
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- NCIT_C115969 type Class @default.
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- NCIT_C115969 label "Hsp70-peptide TKD/IL-2-activated Autologous Natural Killer Cells" @default.
- NCIT_C115969 subClassOf NCIT_C115969 @default.
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