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- NCIT_C115976 IAO_0000115 "An engineered lentiviral vector targeting dendritic cells (DCs) and containing nucleic acids encoding for the human tumor-associated cancer-testis antigen NY-ESO-1, with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, the DC-targeting lentiviral vector ID-LV305 targets and binds to dermal DCs via the DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) receptor. Upon internalization of the vector, the NY-ESO-1 protein is expressed, stimulates DC maturation and activates the immune system to mount a cytotoxic T-lymphocyte (CTL) response against NY-ESO-1-expressing cells, which may result in tumor cell lysis. NY-ESO-1 is expressed in normal testes and on the surfaces of various tumor cells, and plays a key role in tumor cell proliferation and survival." @default.
- NCIT_C115976 NCIT_A32 NCIT_C1909 @default.
- NCIT_C115976 NCIT_NHC0 "C115976" @default.
- NCIT_C115976 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C115976 NCIT_P108 "Dendritic Cell-targeting Lentiviral Vector ID-LV305" @default.
- NCIT_C115976 NCIT_P208 "CL473308" @default.
- NCIT_C115976 NCIT_P322 "GDC" @default.
- NCIT_C115976 NCIT_P329 "760531" @default.
- NCIT_C115976 NCIT_P330 "760531" @default.
- NCIT_C115976 NCIT_P375 "Dendritic Cell-targeting Lentiviral Vector ID-LV305" @default.
- NCIT_C115976 NCIT_P399 "760531" @default.
- NCIT_C115976 normalizedInformationContent "100" @default.
- NCIT_C115976 referenceCount "1" @default.
- NCIT_C115976 hasExactSynonym "DCvex-NY-ESO-1" @default.
- NCIT_C115976 hasExactSynonym "Dendritic Cell-targeting Lentiviral Vector ID-LV305" @default.
- NCIT_C115976 hasExactSynonym "ID-LV305" @default.
- NCIT_C115976 inSubset NCIT_C128784 @default.
- NCIT_C115976 inSubset NCIT_C157711 @default.
- NCIT_C115976 inSubset NCIT_C157712 @default.
- NCIT_C115976 inSubset NCIT_C176424 @default.
- NCIT_C115976 inSubset NCIT_C177537 @default.
- NCIT_C115976 type Class @default.
- NCIT_C115976 isDefinedBy ncit.owl @default.
- NCIT_C115976 label "Dendritic Cell-targeting Lentiviral Vector ID-LV305" @default.
- NCIT_C115976 subClassOf NCIT_C115976 @default.
- NCIT_C115976 subClassOf NCIT_C129820 @default.
- NCIT_C115976 subClassOf NCIT_C129821 @default.
- NCIT_C115976 subClassOf NCIT_C129826 @default.
- NCIT_C115976 subClassOf NCIT_C142078 @default.
- NCIT_C115976 subClassOf NCIT_C1572 @default.
- NCIT_C115976 subClassOf NCIT_C1908 @default.
- NCIT_C115976 subClassOf NCIT_C1909 @default.
- NCIT_C115976 subClassOf NCIT_C274 @default.
- NCIT_C115976 subClassOf NCIT_C307 @default.
- NCIT_C115976 subClassOf NCIT_C308 @default.
- NCIT_C115976 subClassOf NCIT_C923 @default.
- NCIT_C115976 subClassOf NCIT_C96404 @default.