Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C115977> ?p ?o ?g. }
Showing items 1 to 41 of
41
with 100 items per page.
- NCIT_C115977 IAO_0000115 "An orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival." @default.
- NCIT_C115977 NCIT_A32 NCIT_C1909 @default.
- NCIT_C115977 NCIT_A5 NCIT_C156895 @default.
- NCIT_C115977 NCIT_NHC0 "C115977" @default.
- NCIT_C115977 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C115977 NCIT_P108 "Larotrectinib" @default.
- NCIT_C115977 NCIT_P207 "C4278057" @default.
- NCIT_C115977 NCIT_P210 "1223403-58-4" @default.
- NCIT_C115977 NCIT_P319 "PF9462I9HX" @default.
- NCIT_C115977 NCIT_P322 "FDA" @default.
- NCIT_C115977 NCIT_P322 "GDC" @default.
- NCIT_C115977 NCIT_P375 "Larotrectinib" @default.
- NCIT_C115977 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C115977 referenceCount "3" @default.
- NCIT_C115977 hasExactSynonym "1-Pyrrolidinecarboxamide, N-(5-((2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxy-, (3S)-" @default.
- NCIT_C115977 hasExactSynonym "3S)-N-(5-((2R)-2-(2,5-Difluorophenyl)pyrrolidin-1-yl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxypyrrolidine- 1-carboxamide" @default.
- NCIT_C115977 hasExactSynonym "ARRY 470" @default.
- NCIT_C115977 hasExactSynonym "LAROTRECTINIB" @default.
- NCIT_C115977 hasExactSynonym "LOXO 101" @default.
- NCIT_C115977 hasExactSynonym "LOXO-101" @default.
- NCIT_C115977 hasExactSynonym "Larotrectinib" @default.
- NCIT_C115977 inSubset NCIT_C128784 @default.
- NCIT_C115977 inSubset NCIT_C157711 @default.
- NCIT_C115977 inSubset NCIT_C157712 @default.
- NCIT_C115977 inSubset NCIT_C177537 @default.
- NCIT_C115977 inSubset NCIT_C63923 @default.
- NCIT_C115977 type Class @default.
- NCIT_C115977 isDefinedBy ncit.owl @default.
- NCIT_C115977 label "Larotrectinib" @default.
- NCIT_C115977 subClassOf NCIT_C115977 @default.
- NCIT_C115977 subClassOf NCIT_C129824 @default.
- NCIT_C115977 subClassOf NCIT_C129825 @default.
- NCIT_C115977 subClassOf NCIT_C1404 @default.
- NCIT_C115977 subClassOf NCIT_C155765 @default.
- NCIT_C115977 subClassOf NCIT_C163758 @default.
- NCIT_C115977 subClassOf NCIT_C1908 @default.
- NCIT_C115977 subClassOf NCIT_C1909 @default.
- NCIT_C115977 subClassOf NCIT_C1967 @default.
- NCIT_C115977 subClassOf NCIT_C2189 @default.
- NCIT_C115977 subClassOf NCIT_C274 @default.
- NCIT_C115977 subClassOf NCIT_C471 @default.