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- NCIT_C115979 IAO_0000115 "Human autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-DP0401/0402-restricted, melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. CD4-positive cells are isolated from a patient, transduced with an anti-MAGE-A3-DP0401/0402 restricted TCR, expanded ex vivo, and reintroduced into the HLA-DP0401/0402 positive patient. Then, the HLA-DP0401/0402-restricted, MAGE-A3-reactive TCR-transduced autologous T cells bind to tumor cells expressing the MAGE-A3 antigen, which may result in both an inhibition of growth and increased cell death for MAGE-A3-expressing cancer cells. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types." @default.
- NCIT_C115979 NCIT_NHC0 "C115979" @default.
- NCIT_C115979 NCIT_P106 "Cell" @default.
- NCIT_C115979 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C115979 NCIT_P108 "HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells" @default.
- NCIT_C115979 NCIT_P208 "CL473311" @default.
- NCIT_C115979 NCIT_P329 "760677" @default.
- NCIT_C115979 NCIT_P330 "760677" @default.
- NCIT_C115979 NCIT_P399 "760677" @default.
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- NCIT_C115979 NCIT_R72 NCIT_C104083 @default.
- NCIT_C115979 NCIT_R72 NCIT_C12219 @default.
- NCIT_C115979 NCIT_R72 NCIT_C12476 @default.
- NCIT_C115979 NCIT_R72 NCIT_C12508 @default.
- NCIT_C115979 NCIT_R72 NCIT_C12535 @default.
- NCIT_C115979 NCIT_R72 NCIT_C12542 @default.
- NCIT_C115979 NCIT_R72 NCIT_C12543 @default.
- NCIT_C115979 NCIT_R72 NCIT_C21599 @default.
- NCIT_C115979 NCIT_R72 NCIT_C32725 @default.
- NCIT_C115979 NCIT_R72 NCIT_C33061 @default.
- NCIT_C115979 NCIT_R72 NCIT_C38434 @default.
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- NCIT_C115979 normalizedInformationContent "100" @default.
- NCIT_C115979 referenceCount "1" @default.
- NCIT_C115979 hasExactSynonym "Anti-MAGE-A3-DP4 TCR PBL" @default.
- NCIT_C115979 hasExactSynonym "HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells" @default.
- NCIT_C115979 inSubset NCIT_C128784 @default.
- NCIT_C115979 inSubset NCIT_C176424 @default.
- NCIT_C115979 type Class @default.
- NCIT_C115979 isDefinedBy ncit.owl @default.
- NCIT_C115979 label "HLA-DP0401/0402-Restricted MAGE-A3-Reactive T Cell Receptor-transduced Autologous T Cells" @default.
- NCIT_C115979 subClassOf NCIT_C115979 @default.
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- NCIT_C115979 subClassOf NCIT_C1908 @default.
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- NCIT_C115979 subClassOf NCIT_C1962 @default.
- NCIT_C115979 subClassOf NCIT_C274 @default.
- NCIT_C115979 subClassOf NCIT_C28681 @default.
- NCIT_C115979 subClassOf NCIT_C307 @default.
- NCIT_C115979 subClassOf NCIT_C308 @default.