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- NCIT_C116064 IAO_0000115 "A formulation composed of the hydrochloride salt form of the anthracenedione antibiotic mitoxantrone encapsulated within liposomes, with potential antineoplastic activity. Upon intravenous administration, mitoxantrone intercalates into and forms crosslinks with DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, which both results in DNA strand breaks and prevents DNA synthesis. This leads to the induction of apoptosis in the rapidly dividing cancer cells. The liposomal delivery of mitoxantrone improves drug penetration into tumors and decreases drug clearance, thereby increasing drug circulation and therapeutic efficacy while lowering the toxic effects." @default.
- NCIT_C116064 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116064 NCIT_NHC0 "C116064" @default.
- NCIT_C116064 NCIT_P106 "Organic Chemical" @default.
- NCIT_C116064 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116064 NCIT_P108 "Liposomal Mitoxantrone Hydrochloride" @default.
- NCIT_C116064 NCIT_P208 "CL473483" @default.
- NCIT_C116064 NCIT_P322 "GDC" @default.
- NCIT_C116064 NCIT_P329 "760808" @default.
- NCIT_C116064 NCIT_P330 "760808" @default.
- NCIT_C116064 NCIT_P375 "Liposomal Mitoxantrone Hydrochloride" @default.
- NCIT_C116064 NCIT_P399 "760808" @default.
- NCIT_C116064 normalizedInformationContent "100" @default.
- NCIT_C116064 referenceCount "1" @default.
- NCIT_C116064 hasExactSynonym "Liposomal Mitoxantrone Hydrochloride" @default.
- NCIT_C116064 hasExactSynonym "Mitoxantrone Hydrochloride Liposome" @default.
- NCIT_C116064 inSubset NCIT_C128784 @default.
- NCIT_C116064 inSubset NCIT_C157711 @default.
- NCIT_C116064 inSubset NCIT_C157712 @default.
- NCIT_C116064 inSubset NCIT_C176424 @default.
- NCIT_C116064 inSubset NCIT_C177537 @default.
- NCIT_C116064 type Class @default.
- NCIT_C116064 isDefinedBy ncit.owl @default.
- NCIT_C116064 label "Liposomal Mitoxantrone Hydrochloride" @default.
- NCIT_C116064 subClassOf NCIT_C116064 @default.
- NCIT_C116064 subClassOf NCIT_C129824 @default.
- NCIT_C116064 subClassOf NCIT_C129825 @default.
- NCIT_C116064 subClassOf NCIT_C1748 @default.
- NCIT_C116064 subClassOf NCIT_C186664 @default.
- NCIT_C116064 subClassOf NCIT_C1908 @default.
- NCIT_C116064 subClassOf NCIT_C1909 @default.
- NCIT_C116064 subClassOf NCIT_C1913 @default.
- NCIT_C116064 subClassOf NCIT_C1915 @default.
- NCIT_C116064 subClassOf NCIT_C1933 @default.
- NCIT_C116064 subClassOf NCIT_C1968 @default.
- NCIT_C116064 subClassOf NCIT_C200714 @default.
- NCIT_C116064 subClassOf NCIT_C2189 @default.
- NCIT_C116064 subClassOf NCIT_C253 @default.
- NCIT_C116064 subClassOf NCIT_C274 @default.
- NCIT_C116064 subClassOf NCIT_C2842 @default.
- NCIT_C116064 subClassOf NCIT_C471 @default.
- NCIT_C116064 subClassOf NCIT_C552 @default.
- NCIT_C116064 subClassOf NCIT_C553 @default.
- NCIT_C116064 subClassOf NCIT_C582 @default.
- NCIT_C116064 subClassOf NCIT_C718 @default.
- NCIT_C116064 subClassOf NCIT_C796 @default.
- NCIT_C116064 subClassOf NCIT_C94716 @default.