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- NCIT_C116065 IAO_0000115 "An anti-human glucocorticoid-induced tumor necrosis factor receptor (GITR) agonistic monoclonal antibody (MoAb) with potential immunomodulating activity. Anti-GITR monoclonal antibody MK-4166 binds to and activates GITRs found on multiple types of T-cells. This stimulates the immune system and induces both the activation and proliferation of tumor-antigen-specific T effector cells, and suppresses the function of activated T regulatory cells. This leads to tumor cell eradication. Also, this agent is shown to act synergistically with chemotherapeutic drugs in multiple cancer models. GITR, a member of the TNF receptor superfamily, is expressed on the surface of multiple types of immune cells, including regulatory T-cells, effector T-cells, B-cells, and natural killer (NK) cells." @default.
- NCIT_C116065 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116065 NCIT_A7 NCIT_C105568 @default.
- NCIT_C116065 NCIT_NHC0 "C116065" @default.
- NCIT_C116065 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116065 NCIT_P108 "Anti-GITR Monoclonal Antibody MK-4166" @default.
- NCIT_C116065 NCIT_P208 "CL473484" @default.
- NCIT_C116065 NCIT_P322 "GDC" @default.
- NCIT_C116065 NCIT_P329 "760889" @default.
- NCIT_C116065 NCIT_P330 "760889" @default.
- NCIT_C116065 NCIT_P375 "Anti-GITR Monoclonal Antibody MK-4166" @default.
- NCIT_C116065 NCIT_P399 "760889" @default.
- NCIT_C116065 NCIT_R124 NCIT_C17710 @default.
- NCIT_C116065 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116065 NCIT_R124 NCIT_C18219 @default.
- NCIT_C116065 NCIT_R124 NCIT_C19986 @default.
- NCIT_C116065 NCIT_R124 NCIT_C40474 @default.
- NCIT_C116065 normalizedInformationContent "100" @default.
- NCIT_C116065 referenceCount "1" @default.
- NCIT_C116065 hasExactSynonym "Anti-GITR Monoclonal Antibody MK-4166" @default.
- NCIT_C116065 hasExactSynonym "MK-4166" @default.
- NCIT_C116065 inSubset NCIT_C128784 @default.
- NCIT_C116065 inSubset NCIT_C157711 @default.
- NCIT_C116065 inSubset NCIT_C157712 @default.
- NCIT_C116065 inSubset NCIT_C176424 @default.
- NCIT_C116065 inSubset NCIT_C177537 @default.
- NCIT_C116065 type Class @default.
- NCIT_C116065 isDefinedBy ncit.owl @default.
- NCIT_C116065 label "Anti-GITR Monoclonal Antibody MK-4166" @default.
- NCIT_C116065 subClassOf NCIT_C116065 @default.
- NCIT_C116065 subClassOf NCIT_C128058 @default.
- NCIT_C116065 subClassOf NCIT_C129820 @default.
- NCIT_C116065 subClassOf NCIT_C129821 @default.
- NCIT_C116065 subClassOf NCIT_C129822 @default.
- NCIT_C116065 subClassOf NCIT_C141144 @default.
- NCIT_C116065 subClassOf NCIT_C1908 @default.
- NCIT_C116065 subClassOf NCIT_C1909 @default.
- NCIT_C116065 subClassOf NCIT_C201119 @default.
- NCIT_C116065 subClassOf NCIT_C20401 @default.
- NCIT_C116065 subClassOf NCIT_C274 @default.
- NCIT_C116065 subClassOf NCIT_C307 @default.
- NCIT_C116065 subClassOf NCIT_C308 @default.