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- NCIT_C116074 IAO_0000115 "An orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase, with potential antineoplastic activity. Upon administration, empesertib binds to and inhibits the activity of Mps1. This causes inactivation of the spindle assembly checkpoint (SAC), accelerated mitosis, chromosomal misalignment, chromosomal missegregation, mitotic checkpoint complex destabilization, and increased aneuploidy. This leads to the induction of cell death in cancer cells overexpressing Mps1. Mps1, a kinase expressed in proliferating normal tissues and aberrantly overexpressed in a wide range of human tumors, is activated during mitosis and is essential for SAC functioning and controls chromosome alignment." @default.
- NCIT_C116074 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116074 NCIT_NHC0 "C116074" @default.
- NCIT_C116074 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116074 NCIT_P108 "Empesertib" @default.
- NCIT_C116074 NCIT_P208 "CL473492" @default.
- NCIT_C116074 NCIT_P210 "1443763-60-7" @default.
- NCIT_C116074 NCIT_P319 "02Y3Z2756M" @default.
- NCIT_C116074 NCIT_P322 "FDA" @default.
- NCIT_C116074 NCIT_P322 "GDC" @default.
- NCIT_C116074 NCIT_P329 "761238" @default.
- NCIT_C116074 NCIT_P330 "761238" @default.
- NCIT_C116074 NCIT_P375 "Empesertib" @default.
- NCIT_C116074 NCIT_P399 "761238" @default.
- NCIT_C116074 normalizedInformationContent "100" @default.
- NCIT_C116074 referenceCount "1" @default.
- NCIT_C116074 hasExactSynonym "(2R)-2-(4-Fluorophenyl)-N-(4-(2-((2-methoxy-4-(methylsulfonyl)phenyl)amino)(1,2,4)triazolo(1,5-a)pyridin-6-yl)phenyl)propanamide" @default.
- NCIT_C116074 hasExactSynonym "BAY116-1909" @default.
- NCIT_C116074 hasExactSynonym "BAY1161909" @default.
- NCIT_C116074 hasExactSynonym "EMPESERTIB" @default.
- NCIT_C116074 hasExactSynonym "Empesertib" @default.
- NCIT_C116074 inSubset NCIT_C128784 @default.
- NCIT_C116074 inSubset NCIT_C157711 @default.
- NCIT_C116074 inSubset NCIT_C157712 @default.
- NCIT_C116074 inSubset NCIT_C176424 @default.
- NCIT_C116074 inSubset NCIT_C177537 @default.
- NCIT_C116074 inSubset NCIT_C63923 @default.
- NCIT_C116074 type Class @default.
- NCIT_C116074 isDefinedBy ncit.owl @default.
- NCIT_C116074 label "Empesertib" @default.
- NCIT_C116074 subClassOf NCIT_C116074 @default.
- NCIT_C116074 subClassOf NCIT_C129824 @default.
- NCIT_C116074 subClassOf NCIT_C129825 @default.
- NCIT_C116074 subClassOf NCIT_C1404 @default.
- NCIT_C116074 subClassOf NCIT_C1908 @default.
- NCIT_C116074 subClassOf NCIT_C1909 @default.
- NCIT_C116074 subClassOf NCIT_C2189 @default.
- NCIT_C116074 subClassOf NCIT_C274 @default.
- NCIT_C116074 subClassOf NCIT_C471 @default.
- NCIT_C116074 subClassOf NCIT_C61074 @default.