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- NCIT_C116321 IAO_0000115 "A plasmid DNA vaccine containing the mammalian expression vector pUMVC3 (pNGVL3) encoding epitopes of CD105 (Endoglin), Y-box binding protein 1 (Yb-1), SRY-box 2 (SOX2), cadherin 3 (CDH3), and murine double minute 2 (MDM2) proteins, with potential immunomodulating and antineoplastic activities. Upon intradermal administration of pUMVC3-CD105/Yb-1/SOX2/CDH3/MDM2-epitopes plasmid DNA vaccine, the plasmid transfects cells and the peptides are expressed. This generates a specific memory Th1 (T-helper) cell immune response, stimulates secretion of cytokines by the T cells and leads to a cytotoxic T-lymphocyte (CTL) response against CD105/Yb-1/SOX2/CDH3/MDM2-expressing tumor cells. CD105/Yb-1/SOX2/CDH3/MDM2 proteins are highly immunogenic tumor associated antigens that are overexpressed in breast cancer. Additionally, these antigens are associated with breast cancer stem cells and with epithelial to mesenchymal transformation (EMT)." @default.
- NCIT_C116321 NCIT_NHC0 "C116321" @default.
- NCIT_C116321 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116321 NCIT_P108 "CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine" @default.
- NCIT_C116321 NCIT_P208 "CL473655" @default.
- NCIT_C116321 NCIT_P329 "761274" @default.
- NCIT_C116321 NCIT_P330 "761274" @default.
- NCIT_C116321 NCIT_P399 "761274" @default.
- NCIT_C116321 normalizedInformationContent "100" @default.
- NCIT_C116321 referenceCount "1" @default.
- NCIT_C116321 hasExactSynonym "CD105/Yb-1/SOX2/CDH3/MDM2 Plasmid Vaccine" @default.
- NCIT_C116321 hasExactSynonym "CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine" @default.
- NCIT_C116321 hasExactSynonym "STEMVAC Th1 Polyepitope Plasmid-based Vaccine" @default.
- NCIT_C116321 hasExactSynonym "STEMVAC" @default.
- NCIT_C116321 inSubset NCIT_C128784 @default.
- NCIT_C116321 inSubset NCIT_C176424 @default.
- NCIT_C116321 type Class @default.
- NCIT_C116321 isDefinedBy ncit.owl @default.
- NCIT_C116321 label "CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine" @default.
- NCIT_C116321 subClassOf NCIT_C116321 @default.
- NCIT_C116321 subClassOf NCIT_C129820 @default.
- NCIT_C116321 subClassOf NCIT_C1663 @default.
- NCIT_C116321 subClassOf NCIT_C1908 @default.
- NCIT_C116321 subClassOf NCIT_C1909 @default.
- NCIT_C116321 subClassOf NCIT_C274 @default.
- NCIT_C116321 subClassOf NCIT_C307 @default.
- NCIT_C116321 subClassOf NCIT_C308 @default.
- NCIT_C116321 subClassOf NCIT_C39619 @default.
- NCIT_C116321 subClassOf NCIT_C923 @default.