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- NCIT_C116322 IAO_0000115 "A liposomal formulation containing curcumin, a poorly water-soluble polylphenol pigment isolated from the plant Curcuma longa, with potential antineoplastic, chemopreventive, antioxidant, anti-angiogenic and anti-inflammatory activities. Upon intravenous administration of liposomal curcumin, this agent blocks the formation of reactive-oxygen species, neutralizes free radicals, and exhibits anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation. In addition, curcumin disrupts various cell signal transduction pathways involved in carcinogenesis, inhibits the activity of nuclear factor-kappa B (NF-kB), SRC, and annexin A2 (ANXA2), and reduces the expression of both matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor receptor 2 (VEGFR2). This prevents and/or inhibits tumor cell formation and proliferation. Liposome encapsulation of curcumin improves its efficacy, when compared to the administration of unencapsulated curcumin." @default.
- NCIT_C116322 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116322 NCIT_NHC0 "C116322" @default.
- NCIT_C116322 NCIT_P106 "Organic Chemical" @default.
- NCIT_C116322 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116322 NCIT_P108 "Liposomal Curcumin" @default.
- NCIT_C116322 NCIT_P208 "CL473656" @default.
- NCIT_C116322 NCIT_P322 "GDC" @default.
- NCIT_C116322 NCIT_P329 "761276" @default.
- NCIT_C116322 NCIT_P330 "761276" @default.
- NCIT_C116322 NCIT_P375 "Liposomal Curcumin" @default.
- NCIT_C116322 NCIT_P399 "761276" @default.
- NCIT_C116322 NCIT_R124 NCIT_C17710 @default.
- NCIT_C116322 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116322 NCIT_R124 NCIT_C28498 @default.
- NCIT_C116322 NCIT_R124 NCIT_C40576 @default.
- NCIT_C116322 NCIT_R124 NCIT_C40577 @default.
- NCIT_C116322 normalizedInformationContent "100" @default.
- NCIT_C116322 referenceCount "1" @default.
- NCIT_C116322 hasExactSynonym "Curcumin Liposome" @default.
- NCIT_C116322 hasExactSynonym "Liposomal Curcumin" @default.
- NCIT_C116322 inSubset NCIT_C128784 @default.
- NCIT_C116322 inSubset NCIT_C157711 @default.
- NCIT_C116322 inSubset NCIT_C157712 @default.
- NCIT_C116322 inSubset NCIT_C176424 @default.
- NCIT_C116322 inSubset NCIT_C177537 @default.
- NCIT_C116322 type Class @default.
- NCIT_C116322 isDefinedBy ncit.owl @default.
- NCIT_C116322 label "Liposomal Curcumin" @default.
- NCIT_C116322 subClassOf B98672ad01042f350e1bbd616afcd0854 @default.
- NCIT_C116322 subClassOf B9cf5b170b52bd1767d1174736ef5056f @default.
- NCIT_C116322 subClassOf NCIT_C116322 @default.
- NCIT_C116322 subClassOf NCIT_C1323 @default.
- NCIT_C116322 subClassOf NCIT_C1742 @default.
- NCIT_C116322 subClassOf NCIT_C1908 @default.
- NCIT_C116322 subClassOf NCIT_C1909 @default.
- NCIT_C116322 subClassOf NCIT_C2198 @default.
- NCIT_C116322 subClassOf NCIT_C2356 @default.
- NCIT_C116322 subClassOf NCIT_C241 @default.
- NCIT_C116322 subClassOf NCIT_C257 @default.
- NCIT_C116322 subClassOf NCIT_C274 @default.
- NCIT_C116322 subClassOf NCIT_C471 @default.
- NCIT_C116322 subClassOf NCIT_C78272 @default.