Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C116329> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- NCIT_C116329 IAO_0000115 "A preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR), containing a CD28 co-stimulatory signaling domain fused to CD3 zeta, the single-chain variable fragment of CD123 (Interleukin-3 receptor alpha chain or IL3RA) antigen, and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes are directed to and induce selective toxicity in CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates detection of the administered T-cells in vivo and can promote elimination of those cells following a cetuximab-induced antibody-dependent cellular cytotoxicity response. The costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents recognition of the CAR by Fc receptors (FcRs)." @default.
- NCIT_C116329 NCIT_NHC0 "C116329" @default.
- NCIT_C116329 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116329 NCIT_P108 "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C116329 NCIT_P208 "CL473663" @default.
- NCIT_C116329 NCIT_P329 "761604" @default.
- NCIT_C116329 NCIT_P330 "761604" @default.
- NCIT_C116329 NCIT_P399 "761604" @default.
- NCIT_C116329 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116329 NCIT_R124 NCIT_C17930 @default.
- NCIT_C116329 NCIT_R124 NCIT_C17937 @default.
- NCIT_C116329 NCIT_R124 NCIT_C18839 @default.
- NCIT_C116329 NCIT_R124 NCIT_C21124 @default.
- NCIT_C116329 NCIT_R124 NCIT_C45548 @default.
- NCIT_C116329 NCIT_R125 NCIT_C17828 @default.
- NCIT_C116329 NCIT_R125 NCIT_C17937 @default.
- NCIT_C116329 NCIT_R125 NCIT_C18095 @default.
- NCIT_C116329 NCIT_R125 NCIT_C18839 @default.
- NCIT_C116329 NCIT_R125 NCIT_C19053 @default.
- NCIT_C116329 NCIT_R125 NCIT_C21124 @default.
- NCIT_C116329 NCIT_R125 NCIT_C26280 @default.
- NCIT_C116329 NCIT_R125 NCIT_C40833 @default.
- NCIT_C116329 NCIT_R125 NCIT_C40912 @default.
- NCIT_C116329 NCIT_R72 NCIT_C104083 @default.
- NCIT_C116329 NCIT_R72 NCIT_C12219 @default.
- NCIT_C116329 NCIT_R72 NCIT_C12476 @default.
- NCIT_C116329 NCIT_R72 NCIT_C12508 @default.
- NCIT_C116329 NCIT_R72 NCIT_C12535 @default.
- NCIT_C116329 NCIT_R72 NCIT_C12542 @default.
- NCIT_C116329 NCIT_R72 NCIT_C12543 @default.
- NCIT_C116329 NCIT_R72 NCIT_C21599 @default.
- NCIT_C116329 NCIT_R72 NCIT_C32725 @default.
- NCIT_C116329 NCIT_R72 NCIT_C33061 @default.
- NCIT_C116329 NCIT_R72 NCIT_C38434 @default.
- NCIT_C116329 NCIT_R72 NCIT_C38439 @default.
- NCIT_C116329 NCIT_R72 NCIT_C39567 @default.
- NCIT_C116329 NCIT_R72 NCIT_C39568 @default.
- NCIT_C116329 normalizedInformationContent "100" @default.
- NCIT_C116329 referenceCount "1" @default.
- NCIT_C116329 hasExactSynonym "Anti CD123-CAR/CD28-costimulatory Lentiviral Vector-transduced Autologous T Lymphocytes" @default.
- NCIT_C116329 hasExactSynonym "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C116329 hasExactSynonym "CD123R(EQ)28zeta/EGFRt+ T Cells" @default.
- NCIT_C116329 inSubset NCIT_C128784 @default.
- NCIT_C116329 inSubset NCIT_C176424 @default.
- NCIT_C116329 type Class @default.
- NCIT_C116329 isDefinedBy ncit.owl @default.
- NCIT_C116329 label "Autologous CD123CAR-CD28-CD3zeta-EGFRt-expressing T Lymphocytes" @default.
- NCIT_C116329 subClassOf NCIT_C116329 @default.
- NCIT_C116329 subClassOf NCIT_C129820 @default.
- NCIT_C116329 subClassOf NCIT_C129821 @default.
- NCIT_C116329 subClassOf NCIT_C129826 @default.
- NCIT_C116329 subClassOf NCIT_C137999 @default.
- NCIT_C116329 subClassOf NCIT_C142078 @default.
- NCIT_C116329 subClassOf NCIT_C154231 @default.
- NCIT_C116329 subClassOf NCIT_C1908 @default.
- NCIT_C116329 subClassOf NCIT_C1909 @default.
- NCIT_C116329 subClassOf NCIT_C1962 @default.
- NCIT_C116329 subClassOf NCIT_C200766 @default.
- NCIT_C116329 subClassOf NCIT_C201493 @default.
- NCIT_C116329 subClassOf NCIT_C274 @default.
- NCIT_C116329 subClassOf NCIT_C28681 @default.
- NCIT_C116329 subClassOf NCIT_C307 @default.
- NCIT_C116329 subClassOf NCIT_C308 @default.