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- NCIT_C116330 IAO_0000115 "Autologous activated T cells that have been coated with bispecific antibodies (BiAb) comprised of anti-CD3 murine monoclonal antibody OKT3 heteroconjugated to anti-GD2 humanized monoclonal antibody 3F8 (hu3F8), with potential antineoplastic and immunomodulating activities. In vitro, T cells are exposed to OKT3, which binds to the T cell receptor-CD3 complex on the T cell surface, crosslinks the CD3 receptors and leads to T cell activation. In turn, the hu3F8 monoclonal antibody is heteroconjugated to OKT3. Upon administration, anti-CD3 x anti-GD2 bispecific antibody-armed activated T cells attach to GD2-expressing tumor cells, thereby selectively cross-linking T cells and tumor cells. This results in selective cytotoxicity towards the GD2-expressing tumor cells. In addition, cytokine and chemokine secretion by the T cells further activates the immune system, which leads to the recruitment and activation of cytotoxic T lymphocytes (CTLs), and additional CTL-mediated tumor-specific cell lysis. GD2, a disialoganglioside and tumor-associated antigen, is overexpressed in a variety of tumor cell types. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction." @default.
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- NCIT_C116330 NCIT_P108 "Anti-CD3 OKT3/Humanized Anti-GD2 3F8 Bispecific Antibody-activated T Lymphocytes" @default.
- NCIT_C116330 NCIT_P208 "CL473664" @default.
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- NCIT_C116330 hasExactSynonym "Anti-CD3 OKT3/Humanized Anti-GD2 3F8 Bispecific Antibody-activated T Lymphocytes" @default.
- NCIT_C116330 hasExactSynonym "Anti-CD3 x hu3F8 Bispecific Antibody Armed ATC" @default.
- NCIT_C116330 hasExactSynonym "GD2Bi-aATC" @default.
- NCIT_C116330 hasExactSynonym "Hu3F8Bi Armed ATC" @default.
- NCIT_C116330 hasExactSynonym "OKT3/Humanized 3F8 Bispecific Antibody-activated T Lymphocytes" @default.
- NCIT_C116330 inSubset NCIT_C128784 @default.
- NCIT_C116330 inSubset NCIT_C176424 @default.
- NCIT_C116330 type Class @default.
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- NCIT_C116330 label "Anti-CD3 OKT3/Humanized Anti-GD2 3F8 Bispecific Antibody-activated T Lymphocytes" @default.
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