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- NCIT_C116353 IAO_0000115 "Autologous peripheral blood mononuclear cells (PBMCs) transfected ex vivo with small-interfering ribonucleic acid (siRNA) directed against the E3 ubiquitin ligase casitas B-lineage lymphoma-b gene (Cbl-b), with potential immunoactivating and antineoplastic activities. The Cbl-b gene is silenced ex vivo through the binding of Cbl-b siRNA to Cbl-b mRNA, which prevents the translation of the Cbl-b protein in T-lymphocytes. Upon infusion, the activated, Cbl-b-silenced T-lymphocytes are able to increase the production of cytokines, proliferate and activate the immune system, which leads to cancer cell eradication. Cbl-b, a negative regulator of the immune system, is mutated in a variety of cancer cell types. Its expression is inversely correlated with activation of T-lymphocytes and tumor cell eradication." @default.
- NCIT_C116353 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116353 NCIT_NHC0 "C116353" @default.
- NCIT_C116353 NCIT_P106 "Cell" @default.
- NCIT_C116353 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116353 NCIT_P108 "siRNA-transfected Peripheral Blood Mononuclear Cells APN401" @default.
- NCIT_C116353 NCIT_P208 "CL473671" @default.
- NCIT_C116353 NCIT_P322 "GDC" @default.
- NCIT_C116353 NCIT_P329 "761870" @default.
- NCIT_C116353 NCIT_P330 "761870" @default.
- NCIT_C116353 NCIT_P375 "siRNA-transfected Peripheral Blood Mononuclear Cells APN401" @default.
- NCIT_C116353 NCIT_P399 "761870" @default.
- NCIT_C116353 normalizedInformationContent "100" @default.
- NCIT_C116353 referenceCount "1" @default.
- NCIT_C116353 hasExactSynonym "APN401" @default.
- NCIT_C116353 hasExactSynonym "siRNA-transfected PBMC APN401" @default.
- NCIT_C116353 hasExactSynonym "siRNA-transfected Peripheral Blood Mononuclear Cells APN401" @default.
- NCIT_C116353 inSubset NCIT_C128784 @default.
- NCIT_C116353 inSubset NCIT_C157711 @default.
- NCIT_C116353 inSubset NCIT_C157712 @default.
- NCIT_C116353 inSubset NCIT_C176424 @default.
- NCIT_C116353 inSubset NCIT_C177537 @default.
- NCIT_C116353 type Class @default.
- NCIT_C116353 isDefinedBy ncit.owl @default.
- NCIT_C116353 label "siRNA-transfected Peripheral Blood Mononuclear Cells APN401" @default.
- NCIT_C116353 subClassOf NCIT_C116353 @default.
- NCIT_C116353 subClassOf NCIT_C129820 @default.
- NCIT_C116353 subClassOf NCIT_C129821 @default.
- NCIT_C116353 subClassOf NCIT_C129826 @default.
- NCIT_C116353 subClassOf NCIT_C142078 @default.
- NCIT_C116353 subClassOf NCIT_C1908 @default.
- NCIT_C116353 subClassOf NCIT_C1909 @default.
- NCIT_C116353 subClassOf NCIT_C274 @default.
- NCIT_C116353 subClassOf NCIT_C307 @default.
- NCIT_C116353 subClassOf NCIT_C308 @default.