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- NCIT_C116355 IAO_0000115 "An inhibitor of ataxia telangiectasia and rad3-related (ATR) kinase, a DNA damage response kinase, with potential antineoplastic activity. Upon administration, berzosertib selectively binds to and inhibits ATR kinase activity and prevents ATR-mediated signaling in the ATR-checkpoint kinase 1 (Chk1) signaling pathway. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression, and survival; it is activated by DNA damage caused during DNA replication-associated stress." @default.
- NCIT_C116355 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116355 NCIT_A7 NCIT_C21430 @default.
- NCIT_C116355 NCIT_NHC0 "C116355" @default.
- NCIT_C116355 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116355 NCIT_P107 "Berzosertib" @default.
- NCIT_C116355 NCIT_P108 "Berzosertib" @default.
- NCIT_C116355 NCIT_P207 "C3896746" @default.
- NCIT_C116355 NCIT_P210 "1232416-25-9" @default.
- NCIT_C116355 NCIT_P319 "L423PRV3V3" @default.
- NCIT_C116355 NCIT_P322 "CTRP" @default.
- NCIT_C116355 NCIT_P322 "FDA" @default.
- NCIT_C116355 NCIT_P322 "GDC" @default.
- NCIT_C116355 NCIT_P329 "761970" @default.
- NCIT_C116355 NCIT_P330 "761970" @default.
- NCIT_C116355 NCIT_P375 "ATR Kinase Inhibitor M6620" @default.
- NCIT_C116355 NCIT_P375 "Berzosertib" @default.
- NCIT_C116355 NCIT_P399 "761970" @default.
- NCIT_C116355 normalizedInformationContent "100" @default.
- NCIT_C116355 referenceCount "1" @default.
- NCIT_C116355 hasExactSynonym "2-Pyrazinamine, 3-(3-(4-((Methylamino)methyl)phenyl)-5-isoxazolyl)-5-(4-((1-methylethyl)sulfonyl)phenyl)-" @default.
- NCIT_C116355 hasExactSynonym "BERZOSERTIB" @default.
- NCIT_C116355 hasExactSynonym "Berzosertib" @default.
- NCIT_C116355 hasExactSynonym "M 6620" @default.
- NCIT_C116355 hasExactSynonym "M6620" @default.
- NCIT_C116355 hasExactSynonym "VX 970" @default.
- NCIT_C116355 hasExactSynonym "VX-970" @default.
- NCIT_C116355 hasExactSynonym "VX970" @default.
- NCIT_C116355 inSubset NCIT_C116977 @default.
- NCIT_C116355 inSubset NCIT_C116978 @default.
- NCIT_C116355 inSubset NCIT_C128784 @default.
- NCIT_C116355 inSubset NCIT_C157711 @default.
- NCIT_C116355 inSubset NCIT_C157712 @default.
- NCIT_C116355 inSubset NCIT_C176424 @default.
- NCIT_C116355 inSubset NCIT_C177537 @default.
- NCIT_C116355 inSubset NCIT_C63923 @default.
- NCIT_C116355 type Class @default.
- NCIT_C116355 isDefinedBy ncit.owl @default.
- NCIT_C116355 label "Berzosertib" @default.
- NCIT_C116355 subClassOf NCIT_C116355 @default.
- NCIT_C116355 subClassOf NCIT_C129824 @default.
- NCIT_C116355 subClassOf NCIT_C129825 @default.
- NCIT_C116355 subClassOf NCIT_C1404 @default.
- NCIT_C116355 subClassOf NCIT_C155926 @default.
- NCIT_C116355 subClassOf NCIT_C1908 @default.
- NCIT_C116355 subClassOf NCIT_C1909 @default.
- NCIT_C116355 subClassOf NCIT_C2189 @default.
- NCIT_C116355 subClassOf NCIT_C274 @default.
- NCIT_C116355 subClassOf NCIT_C471 @default.
- NCIT_C116355 subClassOf NCIT_C61074 @default.