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- NCIT_C116377 IAO_0000115 "A third-generation, orally available, irreversible, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, osimertinib covalently binds to and inhibits the activity of numerous mutant forms of EGFR, including the secondarily-acquired resistance mutation T790M, L858R, and exon 19 deletions, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors which also inhibit wild-type EGFR." @default.
- NCIT_C116377 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116377 NCIT_NHC0 "C116377" @default.
- NCIT_C116377 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116377 NCIT_P107 "Osimertinib" @default.
- NCIT_C116377 NCIT_P108 "Osimertinib" @default.
- NCIT_C116377 NCIT_P207 "C3896906" @default.
- NCIT_C116377 NCIT_P210 "1421373-65-0" @default.
- NCIT_C116377 NCIT_P302 "metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC)" @default.
- NCIT_C116377 NCIT_P319 "3C06JJ0Z2O" @default.
- NCIT_C116377 NCIT_P322 "CTRP" @default.
- NCIT_C116377 NCIT_P322 "FDA" @default.
- NCIT_C116377 NCIT_P322 "GDC" @default.
- NCIT_C116377 NCIT_P329 "747632" @default.
- NCIT_C116377 NCIT_P330 "747632" @default.
- NCIT_C116377 NCIT_P375 "Osimertinib" @default.
- NCIT_C116377 NCIT_P399 "747632" @default.
- NCIT_C116377 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C116377 referenceCount "2" @default.
- NCIT_C116377 hasExactSynonym "2-Propenamide, N-(2-((2-(dimethylamino)ethyl)methylamino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)phenyl)-" @default.
- NCIT_C116377 hasExactSynonym "AZD-9291" @default.
- NCIT_C116377 hasExactSynonym "AZD9291" @default.
- NCIT_C116377 hasExactSynonym "Mereletinib" @default.
- NCIT_C116377 hasExactSynonym "OSIMERTINIB" @default.
- NCIT_C116377 hasExactSynonym "Osimertinib" @default.
- NCIT_C116377 inSubset NCIT_C116977 @default.
- NCIT_C116377 inSubset NCIT_C116978 @default.
- NCIT_C116377 inSubset NCIT_C128784 @default.
- NCIT_C116377 inSubset NCIT_C157711 @default.
- NCIT_C116377 inSubset NCIT_C157712 @default.
- NCIT_C116377 inSubset NCIT_C176424 @default.
- NCIT_C116377 inSubset NCIT_C177537 @default.
- NCIT_C116377 inSubset NCIT_C63923 @default.
- NCIT_C116377 type Class @default.
- NCIT_C116377 isDefinedBy ncit.owl @default.
- NCIT_C116377 label "Osimertinib" @default.
- NCIT_C116377 subClassOf NCIT_C116377 @default.
- NCIT_C116377 subClassOf NCIT_C129824 @default.
- NCIT_C116377 subClassOf NCIT_C129825 @default.
- NCIT_C116377 subClassOf NCIT_C1404 @default.
- NCIT_C116377 subClassOf NCIT_C163758 @default.
- NCIT_C116377 subClassOf NCIT_C163952 @default.
- NCIT_C116377 subClassOf NCIT_C1908 @default.
- NCIT_C116377 subClassOf NCIT_C1909 @default.
- NCIT_C116377 subClassOf NCIT_C1967 @default.
- NCIT_C116377 subClassOf NCIT_C2167 @default.
- NCIT_C116377 subClassOf NCIT_C2189 @default.
- NCIT_C116377 subClassOf NCIT_C274 @default.
- NCIT_C116377 subClassOf NCIT_C471 @default.