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- NCIT_C1164 IAO_0000115 "A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus. Bioreduced mitomycin A generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Mitomycin A is more toxic than mitomycin C due to increased and nonselective DNA cross-linking in both aerobic and hypoxic cells. (NCI04)" @default.
- NCIT_C1164 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1164 NCIT_NHC0 "C1164" @default.
- NCIT_C1164 NCIT_P106 "Antibiotic" @default.
- NCIT_C1164 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1164 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1164 NCIT_P108 "Mitomycin A" @default.
- NCIT_C1164 NCIT_P175 "75986" @default.
- NCIT_C1164 NCIT_P207 "C0066608" @default.
- NCIT_C1164 NCIT_P210 "4055-39-4" @default.
- NCIT_C1164 NCIT_P319 "87TMG6FJHV" @default.
- NCIT_C1164 NCIT_P322 "FDA" @default.
- NCIT_C1164 NCIT_P322 "GDC" @default.
- NCIT_C1164 NCIT_P366 "Mitomycin_A" @default.
- NCIT_C1164 NCIT_P375 "Mitomycin A" @default.
- NCIT_C1164 normalizedInformationContent "100" @default.
- NCIT_C1164 referenceCount "1" @default.
- NCIT_C1164 hasExactSynonym "Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6,8a-dimethoxy-5-methyl-, carbamate (ester)" @default.
- NCIT_C1164 hasExactSynonym "MITOMYCIN A" @default.
- NCIT_C1164 hasExactSynonym "Mitomycin A" @default.
- NCIT_C1164 inSubset NCIT_C128784 @default.
- NCIT_C1164 inSubset NCIT_C157711 @default.
- NCIT_C1164 inSubset NCIT_C157712 @default.
- NCIT_C1164 inSubset NCIT_C177537 @default.
- NCIT_C1164 inSubset NCIT_C63923 @default.
- NCIT_C1164 type Class @default.
- NCIT_C1164 isDefinedBy ncit.owl @default.
- NCIT_C1164 label "Mitomycin A" @default.
- NCIT_C1164 subClassOf NCIT_C1164 @default.
- NCIT_C1164 subClassOf NCIT_C1590 @default.
- NCIT_C1164 subClassOf NCIT_C186664 @default.
- NCIT_C1164 subClassOf NCIT_C1908 @default.
- NCIT_C1164 subClassOf NCIT_C1909 @default.
- NCIT_C1164 subClassOf NCIT_C259 @default.
- NCIT_C1164 subClassOf NCIT_C274 @default.
- NCIT_C1164 subClassOf NCIT_C2842 @default.
- NCIT_C1164 subClassOf NCIT_C292 @default.
- NCIT_C1164 subClassOf NCIT_C663 @default.