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- NCIT_C116619 IAO_0000115 "A human, agonistic immunoglobulin (Ig) G2 monoclonal antibody (mAb) targeting 4-1BB (CD137, TNFRSF9), with potential immunostimulating activity. Upon administration, utomilumab binds to and activates 4-1BB expressed on various immune cells, such as CD8-positive and CD4-positive T cells and natural killer (NK) cells. This enhances 4-1BB-mediated signaling, induces cytokine production and promotes anti-tumor immune responses. 4-1BB, a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) family of receptors, plays an important role in the regulation of immune responses." @default.
- NCIT_C116619 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116619 NCIT_A7 NCIT_C105113 @default.
- NCIT_C116619 NCIT_NHC0 "C116619" @default.
- NCIT_C116619 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C116619 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116619 NCIT_P107 "Utomilumab" @default.
- NCIT_C116619 NCIT_P108 "Utomilumab" @default.
- NCIT_C116619 NCIT_P207 "C3529795" @default.
- NCIT_C116619 NCIT_P210 "1417318-27-4" @default.
- NCIT_C116619 NCIT_P319 "6YY8O697VF" @default.
- NCIT_C116619 NCIT_P322 "CTRP" @default.
- NCIT_C116619 NCIT_P322 "FDA" @default.
- NCIT_C116619 NCIT_P322 "GDC" @default.
- NCIT_C116619 NCIT_P329 "696781" @default.
- NCIT_C116619 NCIT_P330 "696781" @default.
- NCIT_C116619 NCIT_P375 "Utomilumab" @default.
- NCIT_C116619 NCIT_P399 "696781" @default.
- NCIT_C116619 NCIT_R124 NCIT_C17710 @default.
- NCIT_C116619 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116619 NCIT_R124 NCIT_C18219 @default.
- NCIT_C116619 NCIT_R124 NCIT_C19986 @default.
- NCIT_C116619 NCIT_R124 NCIT_C40474 @default.
- NCIT_C116619 normalizedInformationContent "100" @default.
- NCIT_C116619 referenceCount "1" @default.
- NCIT_C116619 hasExactSynonym "PF 05082566" @default.
- NCIT_C116619 hasExactSynonym "PF 5082566" @default.
- NCIT_C116619 hasExactSynonym "PF-05082566" @default.
- NCIT_C116619 hasExactSynonym "PF-2566" @default.
- NCIT_C116619 hasExactSynonym "UTOMILUMAB" @default.
- NCIT_C116619 hasExactSynonym "Utomilumab" @default.
- NCIT_C116619 inSubset NCIT_C116977 @default.
- NCIT_C116619 inSubset NCIT_C116978 @default.
- NCIT_C116619 inSubset NCIT_C128784 @default.
- NCIT_C116619 inSubset NCIT_C157711 @default.
- NCIT_C116619 inSubset NCIT_C157712 @default.
- NCIT_C116619 inSubset NCIT_C176424 @default.
- NCIT_C116619 inSubset NCIT_C177537 @default.
- NCIT_C116619 inSubset NCIT_C63923 @default.
- NCIT_C116619 type Class @default.
- NCIT_C116619 isDefinedBy ncit.owl @default.
- NCIT_C116619 label "Utomilumab" @default.
- NCIT_C116619 subClassOf NCIT_C116619 @default.
- NCIT_C116619 subClassOf NCIT_C129820 @default.
- NCIT_C116619 subClassOf NCIT_C155745 @default.
- NCIT_C116619 subClassOf NCIT_C1908 @default.
- NCIT_C116619 subClassOf NCIT_C1909 @default.
- NCIT_C116619 subClassOf NCIT_C192997 @default.
- NCIT_C116619 subClassOf NCIT_C20401 @default.
- NCIT_C116619 subClassOf NCIT_C274 @default.
- NCIT_C116619 subClassOf NCIT_C307 @default.
- NCIT_C116619 subClassOf NCIT_C308 @default.