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- NCIT_C116627 IAO_0000115 "An immunoglobulin (Ig) G2 monoclonal antibody targeting the proangiogenic cytokines angiopoietin 1 (Ang1) and 2 (Ang2), with potential anti-angiogenic and antineoplastic activities. Upon administration, anti-angiopoietin monoclonal antibody AMG 780 binds to Ang1 and Ang2. This prevents the binding of the angiopoietin ligands to their receptor Tie2 (TEK), an endothelial cell-specific receptor tyrosine kinase. This prevents Tie2-mediated signaling and results in an inhibition of Tie2-expressing, tumor-stimulated endothelial cell proliferation, which prevents angiogenesis and inhibits tumor cell proliferation." @default.
- NCIT_C116627 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116627 NCIT_A7 NCIT_C18042 @default.
- NCIT_C116627 NCIT_A7 NCIT_C18056 @default.
- NCIT_C116627 NCIT_NHC0 "C116627" @default.
- NCIT_C116627 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116627 NCIT_P107 "Anti-angiopoietin Monoclonal Antibody AMG 780" @default.
- NCIT_C116627 NCIT_P108 "Anti-angiopoietin Monoclonal Antibody AMG 780" @default.
- NCIT_C116627 NCIT_P208 "CL421599" @default.
- NCIT_C116627 NCIT_P210 "2473627-81-3" @default.
- NCIT_C116627 NCIT_P319 "C55H82K3JJ" @default.
- NCIT_C116627 NCIT_P322 "CTRP" @default.
- NCIT_C116627 NCIT_P322 "FDA" @default.
- NCIT_C116627 NCIT_P322 "GDC" @default.
- NCIT_C116627 NCIT_P329 "675243" @default.
- NCIT_C116627 NCIT_P330 "675243" @default.
- NCIT_C116627 NCIT_P375 "Anti-angiopoietin Monoclonal Antibody AMG 780" @default.
- NCIT_C116627 NCIT_P399 "675243" @default.
- NCIT_C116627 NCIT_R124 NCIT_C17710 @default.
- NCIT_C116627 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116627 NCIT_R124 NCIT_C18219 @default.
- NCIT_C116627 NCIT_R124 NCIT_C19986 @default.
- NCIT_C116627 NCIT_R124 NCIT_C40474 @default.
- NCIT_C116627 normalizedInformationContent "100" @default.
- NCIT_C116627 referenceCount "1" @default.
- NCIT_C116627 hasExactSynonym "AMG 780" @default.
- NCIT_C116627 hasExactSynonym "AMG-780" @default.
- NCIT_C116627 hasExactSynonym "Anti-angiopoietin Monoclonal Antibody AMG 780" @default.
- NCIT_C116627 inSubset NCIT_C116977 @default.
- NCIT_C116627 inSubset NCIT_C116978 @default.
- NCIT_C116627 inSubset NCIT_C128784 @default.
- NCIT_C116627 inSubset NCIT_C157711 @default.
- NCIT_C116627 inSubset NCIT_C157712 @default.
- NCIT_C116627 inSubset NCIT_C176424 @default.
- NCIT_C116627 inSubset NCIT_C177537 @default.
- NCIT_C116627 inSubset NCIT_C63923 @default.
- NCIT_C116627 type Class @default.
- NCIT_C116627 isDefinedBy ncit.owl @default.
- NCIT_C116627 label "Anti-angiopoietin Monoclonal Antibody AMG 780" @default.
- NCIT_C116627 subClassOf NCIT_C116627 @default.
- NCIT_C116627 subClassOf NCIT_C129821 @default.
- NCIT_C116627 subClassOf NCIT_C129822 @default.
- NCIT_C116627 subClassOf NCIT_C1742 @default.
- NCIT_C116627 subClassOf NCIT_C1908 @default.
- NCIT_C116627 subClassOf NCIT_C1909 @default.
- NCIT_C116627 subClassOf NCIT_C20401 @default.
- NCIT_C116627 subClassOf NCIT_C274 @default.
- NCIT_C116627 subClassOf NCIT_C307 @default.
- NCIT_C116627 subClassOf NCIT_C308 @default.