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- NCIT_C116628 IAO_0000115 "An immunoglobulin (Ig) G1 monoclonal antibody directed against both human epidermal growth factor receptor 3 (HER3 or ERBB3) and human epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Duligotuzumab binds to both EGFR and HER3 and inhibits their activation. This may prevent EGFR/HER3-mediated signaling and inhibit EGFR/HER3-dependent tumor cell proliferation. In addition, MEHD7945A induces antibody-dependent cell-mediated cytotoxicity (ADCC) against EGR/HER3-expressing tumor cells. EGFR and HER3, members of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed in tumors; their expression is associated with both poor prognosis and drug resistance." @default.
- NCIT_C116628 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116628 NCIT_A7 NCIT_C17068 @default.
- NCIT_C116628 NCIT_A7 NCIT_C18490 @default.
- NCIT_C116628 NCIT_NHC0 "C116628" @default.
- NCIT_C116628 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116628 NCIT_P107 "Duligotuzumab" @default.
- NCIT_C116628 NCIT_P108 "Duligotuzumab" @default.
- NCIT_C116628 NCIT_P207 "C3490133" @default.
- NCIT_C116628 NCIT_P210 "1312797-14-0" @default.
- NCIT_C116628 NCIT_P319 "8PMF8YQX2T" @default.
- NCIT_C116628 NCIT_P322 "CTRP" @default.
- NCIT_C116628 NCIT_P322 "FDA" @default.
- NCIT_C116628 NCIT_P322 "GDC" @default.
- NCIT_C116628 NCIT_P329 "686389" @default.
- NCIT_C116628 NCIT_P330 "686389" @default.
- NCIT_C116628 NCIT_P375 "Duligotuzumab" @default.
- NCIT_C116628 NCIT_P399 "686389" @default.
- NCIT_C116628 NCIT_R124 NCIT_C17710 @default.
- NCIT_C116628 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116628 NCIT_R124 NCIT_C18219 @default.
- NCIT_C116628 NCIT_R124 NCIT_C19986 @default.
- NCIT_C116628 NCIT_R124 NCIT_C40474 @default.
- NCIT_C116628 normalizedInformationContent "100" @default.
- NCIT_C116628 referenceCount "1" @default.
- NCIT_C116628 hasExactSynonym "DULIGOTUZUMAB" @default.
- NCIT_C116628 hasExactSynonym "Duligotumab" @default.
- NCIT_C116628 hasExactSynonym "Duligotuzumab" @default.
- NCIT_C116628 hasExactSynonym "MEHD 7945A" @default.
- NCIT_C116628 hasExactSynonym "MEHD-7945A" @default.
- NCIT_C116628 hasExactSynonym "MEHD7945A" @default.
- NCIT_C116628 hasExactSynonym "RG 7597" @default.
- NCIT_C116628 inSubset NCIT_C116977 @default.
- NCIT_C116628 inSubset NCIT_C116978 @default.
- NCIT_C116628 inSubset NCIT_C128784 @default.
- NCIT_C116628 inSubset NCIT_C157711 @default.
- NCIT_C116628 inSubset NCIT_C157712 @default.
- NCIT_C116628 inSubset NCIT_C176424 @default.
- NCIT_C116628 inSubset NCIT_C177537 @default.
- NCIT_C116628 inSubset NCIT_C63923 @default.
- NCIT_C116628 type Class @default.
- NCIT_C116628 isDefinedBy ncit.owl @default.
- NCIT_C116628 label "Duligotuzumab" @default.
- NCIT_C116628 subClassOf NCIT_C116628 @default.
- NCIT_C116628 subClassOf NCIT_C129821 @default.
- NCIT_C116628 subClassOf NCIT_C129822 @default.
- NCIT_C116628 subClassOf NCIT_C163758 @default.
- NCIT_C116628 subClassOf NCIT_C1908 @default.
- NCIT_C116628 subClassOf NCIT_C1909 @default.
- NCIT_C116628 subClassOf NCIT_C199383 @default.
- NCIT_C116628 subClassOf NCIT_C199386 @default.
- NCIT_C116628 subClassOf NCIT_C20401 @default.
- NCIT_C116628 subClassOf NCIT_C274 @default.
- NCIT_C116628 subClassOf NCIT_C307 @default.
- NCIT_C116628 subClassOf NCIT_C308 @default.