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- NCIT_C116629 IAO_0000115 "A non-fucosylated monoclonal antibody directed against the ephrin receptor A3 (EphA3), with potential antineoplastic activity. Upon administration, ifabotuzumab selectively binds to tumor cells expressing EphA3. This blocks both EphA3 activation and EphA3-mediated signaling, and induces apoptosis in EphA3-expressing tumor cells. In addition, ifabotuzumab can stimulate antibody dependent cell-mediated cytotoxicity (ADCC) against EphA3-expressing tumor cells. This agent also prevents tumor cell proliferation by inhibiting both EphA3 signaling and proliferation of endothelial cells in the tumor vasculature. The cell-surface receptor EphA3, a member of the ephrin family of receptor tyrosine kinases (RTKs) that are involved in mammalian development, is overexpressed by a variety of tumor types but is not expressed in normal healthy adult tissues. It plays an important role in tumor cell proliferation. Non-fucosylation of the antibody enhances its ADCC activity." @default.
- NCIT_C116629 NCIT_A32 NCIT_C1909 @default.
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- NCIT_C116629 NCIT_NHC0 "C116629" @default.
- NCIT_C116629 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116629 NCIT_P107 "Ifabotuzumab" @default.
- NCIT_C116629 NCIT_P108 "Ifabotuzumab" @default.
- NCIT_C116629 NCIT_P208 "CL433718" @default.
- NCIT_C116629 NCIT_P210 "1234137-51-9" @default.
- NCIT_C116629 NCIT_P319 "2BN89552WP" @default.
- NCIT_C116629 NCIT_P322 "CTRP" @default.
- NCIT_C116629 NCIT_P322 "FDA" @default.
- NCIT_C116629 NCIT_P322 "GDC" @default.
- NCIT_C116629 NCIT_P329 "686621" @default.
- NCIT_C116629 NCIT_P330 "686621" @default.
- NCIT_C116629 NCIT_P375 "Ifabotuzumab" @default.
- NCIT_C116629 NCIT_P399 "686621" @default.
- NCIT_C116629 NCIT_R124 NCIT_C17710 @default.
- NCIT_C116629 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116629 NCIT_R124 NCIT_C18219 @default.
- NCIT_C116629 NCIT_R124 NCIT_C19986 @default.
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- NCIT_C116629 normalizedInformationContent "100" @default.
- NCIT_C116629 referenceCount "1" @default.
- NCIT_C116629 hasExactSynonym "Fibatuzumab" @default.
- NCIT_C116629 hasExactSynonym "IFABOTUZUMAB" @default.
- NCIT_C116629 hasExactSynonym "Ifabotuzumab" @default.
- NCIT_C116629 hasExactSynonym "KB 004" @default.
- NCIT_C116629 hasExactSynonym "KB-004" @default.
- NCIT_C116629 hasExactSynonym "KB004" @default.
- NCIT_C116629 inSubset NCIT_C116977 @default.
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- NCIT_C116629 inSubset NCIT_C63923 @default.
- NCIT_C116629 type Class @default.
- NCIT_C116629 isDefinedBy ncit.owl @default.
- NCIT_C116629 label "Ifabotuzumab" @default.
- NCIT_C116629 subClassOf NCIT_C116629 @default.
- NCIT_C116629 subClassOf NCIT_C129821 @default.
- NCIT_C116629 subClassOf NCIT_C129822 @default.
- NCIT_C116629 subClassOf NCIT_C1908 @default.
- NCIT_C116629 subClassOf NCIT_C1909 @default.
- NCIT_C116629 subClassOf NCIT_C20401 @default.
- NCIT_C116629 subClassOf NCIT_C274 @default.
- NCIT_C116629 subClassOf NCIT_C307 @default.
- NCIT_C116629 subClassOf NCIT_C308 @default.