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- NCIT_C116720 IAO_0000115 "An orally available thymidylate synthase (TS) inhibitor with potential antineoplastic activity. Upon oral administration, DFP-11207 binds to and inhibits TS. This reduces thymine nucleotide synthesis, inhibits DNA synthesis and cell division, causes DNA damage and leads to tumor cell apoptosis. TS catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP)." @default.
- NCIT_C116720 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116720 NCIT_NHC0 "C116720" @default.
- NCIT_C116720 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116720 NCIT_P108 "Thymidylate Synthase Inhibitor DFP-11207" @default.
- NCIT_C116720 NCIT_P208 "CL473914" @default.
- NCIT_C116720 NCIT_P210 "1296177-16-6" @default.
- NCIT_C116720 NCIT_P319 "33RN5G108E" @default.
- NCIT_C116720 NCIT_P322 "FDA" @default.
- NCIT_C116720 NCIT_P322 "GDC" @default.
- NCIT_C116720 NCIT_P329 "762603" @default.
- NCIT_C116720 NCIT_P330 "762603" @default.
- NCIT_C116720 NCIT_P375 "Thymidylate Synthase Inhibitor DFP-11207" @default.
- NCIT_C116720 NCIT_P399 "762603" @default.
- NCIT_C116720 normalizedInformationContent "100" @default.
- NCIT_C116720 referenceCount "1" @default.
- NCIT_C116720 hasExactSynonym "DFP-11207" @default.
- NCIT_C116720 hasExactSynonym "TS Inhibitor DFP-11207" @default.
- NCIT_C116720 hasExactSynonym "Thymidylate Synthase Inhibitor DFP-11207" @default.
- NCIT_C116720 inSubset NCIT_C128784 @default.
- NCIT_C116720 inSubset NCIT_C157711 @default.
- NCIT_C116720 inSubset NCIT_C157712 @default.
- NCIT_C116720 inSubset NCIT_C176424 @default.
- NCIT_C116720 inSubset NCIT_C177537 @default.
- NCIT_C116720 inSubset NCIT_C63923 @default.
- NCIT_C116720 type Class @default.
- NCIT_C116720 isDefinedBy ncit.owl @default.
- NCIT_C116720 label "Thymidylate Synthase Inhibitor DFP-11207" @default.
- NCIT_C116720 subClassOf NCIT_C116720 @default.
- NCIT_C116720 subClassOf NCIT_C1908 @default.
- NCIT_C116720 subClassOf NCIT_C1909 @default.
- NCIT_C116720 subClassOf NCIT_C2021 @default.
- NCIT_C116720 subClassOf NCIT_C471 @default.