Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C116722> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- NCIT_C116722 IAO_0000115 "An orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-like tyrosine kinase 3 (FLT3; STK1; FLK2), AXL (UFO; JTK11), anaplastic lymphoma kinase (ALK; CD246), and leukocyte receptor tyrosine kinase (LTK), with potential antineoplastic activity. Upon administration, gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL, ALK and LTK. This may result in an inhibition of FLT3-, AXL-, ALK-, and LTK-mediated signal transduction pathways and reduced proliferation in cancer cells that overexpress these RTKs. FLT3, AXL, ALK, and LTK, which are overexpressed or mutated in a variety of cancer cell types, play key roles in tumor cell growth and survival." @default.
- NCIT_C116722 NCIT_A24 NCIT_C274 @default.
- NCIT_C116722 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116722 NCIT_A5 NCIT_C119665 @default.
- NCIT_C116722 NCIT_A7 NCIT_C17475 @default.
- NCIT_C116722 NCIT_A7 NCIT_C26202 @default.
- NCIT_C116722 NCIT_A7 NCIT_C26332 @default.
- NCIT_C116722 NCIT_A7 NCIT_C27032 @default.
- NCIT_C116722 NCIT_NHC0 "C116722" @default.
- NCIT_C116722 NCIT_P106 "Organic Chemical" @default.
- NCIT_C116722 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116722 NCIT_P107 "Gilteritinib" @default.
- NCIT_C116722 NCIT_P108 "Gilteritinib" @default.
- NCIT_C116722 NCIT_P207 "C3896738" @default.
- NCIT_C116722 NCIT_P210 "1254053-43-4" @default.
- NCIT_C116722 NCIT_P302 "relapsed or refractory acute myeloid leukemia (AML)" @default.
- NCIT_C116722 NCIT_P319 "66D92MGC8M" @default.
- NCIT_C116722 NCIT_P322 "CTRP" @default.
- NCIT_C116722 NCIT_P322 "FDA" @default.
- NCIT_C116722 NCIT_P322 "GDC" @default.
- NCIT_C116722 NCIT_P322 "PCDC" @default.
- NCIT_C116722 NCIT_P329 "752319" @default.
- NCIT_C116722 NCIT_P330 "752319" @default.
- NCIT_C116722 NCIT_P375 "Gilteritinib" @default.
- NCIT_C116722 NCIT_P399 "752319" @default.
- NCIT_C116722 normalizedInformationContent "100" @default.
- NCIT_C116722 referenceCount "1" @default.
- NCIT_C116722 hasExactSynonym "6-Ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide" @default.
- NCIT_C116722 hasExactSynonym "ASP-2215" @default.
- NCIT_C116722 hasExactSynonym "ASP2215" @default.
- NCIT_C116722 hasExactSynonym "GILTERITINIB" @default.
- NCIT_C116722 hasExactSynonym "Gilteritinib" @default.
- NCIT_C116722 inSubset NCIT_C116977 @default.
- NCIT_C116722 inSubset NCIT_C116978 @default.
- NCIT_C116722 inSubset NCIT_C128784 @default.
- NCIT_C116722 inSubset NCIT_C157711 @default.
- NCIT_C116722 inSubset NCIT_C157712 @default.
- NCIT_C116722 inSubset NCIT_C173234 @default.
- NCIT_C116722 inSubset NCIT_C174019 @default.
- NCIT_C116722 inSubset NCIT_C176424 @default.
- NCIT_C116722 inSubset NCIT_C177537 @default.
- NCIT_C116722 inSubset NCIT_C63923 @default.
- NCIT_C116722 type Class @default.
- NCIT_C116722 isDefinedBy ncit.owl @default.
- NCIT_C116722 label "Gilteritinib" @default.
- NCIT_C116722 subClassOf NCIT_C116722 @default.
- NCIT_C116722 subClassOf NCIT_C129824 @default.
- NCIT_C116722 subClassOf NCIT_C129825 @default.
- NCIT_C116722 subClassOf NCIT_C1404 @default.
- NCIT_C116722 subClassOf NCIT_C1908 @default.
- NCIT_C116722 subClassOf NCIT_C1909 @default.
- NCIT_C116722 subClassOf NCIT_C1967 @default.
- NCIT_C116722 subClassOf NCIT_C2189 @default.
- NCIT_C116722 subClassOf NCIT_C274 @default.
- NCIT_C116722 subClassOf NCIT_C471 @default.