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- NCIT_C116727 IAO_0000115 "An orally available, small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon oral administration, ASP3026 binds to and inhibits ALK tyrosine kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and the inhibition of cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK is not expressed in healthy adult human tissue but ALK dysregulation and gene rearrangements are associated with a series of tumors. Additionally, ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors." @default.
- NCIT_C116727 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116727 NCIT_A7 NCIT_C27032 @default.
- NCIT_C116727 NCIT_NHC0 "C116727" @default.
- NCIT_C116727 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116727 NCIT_P107 "ALK Inhibitor ASP3026" @default.
- NCIT_C116727 NCIT_P108 "ALK Inhibitor ASP3026" @default.
- NCIT_C116727 NCIT_P207 "C3896911" @default.
- NCIT_C116727 NCIT_P210 "1097917-15-1" @default.
- NCIT_C116727 NCIT_P319 "HP4L6MXF10" @default.
- NCIT_C116727 NCIT_P322 "CTRP" @default.
- NCIT_C116727 NCIT_P322 "FDA" @default.
- NCIT_C116727 NCIT_P322 "GDC" @default.
- NCIT_C116727 NCIT_P329 "694592" @default.
- NCIT_C116727 NCIT_P330 "694592" @default.
- NCIT_C116727 NCIT_P375 "ALK Inhibitor ASP3026" @default.
- NCIT_C116727 NCIT_P399 "694592" @default.
- NCIT_C116727 normalizedInformationContent "100" @default.
- NCIT_C116727 referenceCount "1" @default.
- NCIT_C116727 hasExactSynonym "ALK Inhibitor ASP3026" @default.
- NCIT_C116727 hasExactSynonym "ASP-3026" @default.
- NCIT_C116727 hasExactSynonym "ASP3026" @default.
- NCIT_C116727 hasExactSynonym "N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine" @default.
- NCIT_C116727 inSubset NCIT_C116977 @default.
- NCIT_C116727 inSubset NCIT_C116978 @default.
- NCIT_C116727 inSubset NCIT_C128784 @default.
- NCIT_C116727 inSubset NCIT_C157711 @default.
- NCIT_C116727 inSubset NCIT_C157712 @default.
- NCIT_C116727 inSubset NCIT_C176424 @default.
- NCIT_C116727 inSubset NCIT_C177537 @default.
- NCIT_C116727 inSubset NCIT_C63923 @default.
- NCIT_C116727 type Class @default.
- NCIT_C116727 isDefinedBy ncit.owl @default.
- NCIT_C116727 label "ALK Inhibitor ASP3026" @default.
- NCIT_C116727 subClassOf NCIT_C116727 @default.
- NCIT_C116727 subClassOf NCIT_C1404 @default.
- NCIT_C116727 subClassOf NCIT_C141136 @default.
- NCIT_C116727 subClassOf NCIT_C163758 @default.
- NCIT_C116727 subClassOf NCIT_C1908 @default.
- NCIT_C116727 subClassOf NCIT_C1909 @default.
- NCIT_C116727 subClassOf NCIT_C1967 @default.
- NCIT_C116727 subClassOf NCIT_C274 @default.
- NCIT_C116727 subClassOf NCIT_C471 @default.