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- NCIT_C116734 IAO_0000115 "A preparation of autologous, CD34-positive hematopoietic progenitor cells (HPCs) ex vivo transduced with TNS9.3.55, a lentiviral vector encoding the human beta-globin (hemoglobin-beta, HBB) gene, with potential to restore beta-globin expression and function. Autologous CD34-positive stem cells are isolated from the patient's own bone marrow, the deficient HBB gene is removed, and the cells are transduced with the lentiviral vector. Upon re-infusion of the TNS9.3.55-transduced CD34-positive cells back into the patient, these cells express beta-globin, thereby allowing the body to make normal hemoglobin and thus normal, healthy red blood cells. Beta-globin, the beta-chain of the most common form of hemoglobin, is encoded by the HBB gene; mutations in this gene prevent normal beta-globin production." @default.
- NCIT_C116734 NCIT_NHC0 "C116734" @default.
- NCIT_C116734 NCIT_P106 "Cell" @default.
- NCIT_C116734 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116734 NCIT_P107 "Autologous TNS9.3.55-transduced CD34-positive Cells" @default.
- NCIT_C116734 NCIT_P108 "Autologous TNS9.3.55-transduced CD34-positive Cells" @default.
- NCIT_C116734 NCIT_P208 "CL446651" @default.
- NCIT_C116734 NCIT_P322 "CTRP" @default.
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- NCIT_C116734 normalizedInformationContent "100" @default.
- NCIT_C116734 referenceCount "1" @default.
- NCIT_C116734 hasExactSynonym "Autologous CD34-positive Cells Transduced with TNS9.3.55" @default.
- NCIT_C116734 hasExactSynonym "Autologous TNS9.3.55-transduced CD34-positive Cells" @default.
- NCIT_C116734 inSubset NCIT_C116977 @default.
- NCIT_C116734 inSubset NCIT_C116978 @default.
- NCIT_C116734 type Class @default.
- NCIT_C116734 isDefinedBy ncit.owl @default.
- NCIT_C116734 label "Autologous TNS9.3.55-transduced CD34-positive Cells" @default.
- NCIT_C116734 subClassOf NCIT_C116734 @default.
- NCIT_C116734 subClassOf NCIT_C142078 @default.
- NCIT_C116734 subClassOf NCIT_C154231 @default.
- NCIT_C116734 subClassOf NCIT_C1908 @default.
- NCIT_C116734 subClassOf NCIT_C1909 @default.
- NCIT_C116734 subClassOf NCIT_C1962 @default.
- NCIT_C116734 subClassOf NCIT_C28681 @default.
- NCIT_C116734 subClassOf NCIT_C307 @default.
- NCIT_C116734 subClassOf NCIT_C308 @default.