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- NCIT_C116745 IAO_0000115 "An antibody-drug conjugate (ADC) composed of an antibody against the tumor-associated antigen (TAA) lymphocyte antigen 6 complex locus E (Ly6E) and linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration, the antibody moiety of RG 7841 targets and binds to Ly6E expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills, through an as of yet unknown mechanism of action, the Ly6E-expressing cancer cells. Ly6E, an interferon (IFN)-inducible glycosylphosphatidylinositol (GPI)-linked cell membrane protein, is expressed on a variety of tumor cell types." @default.
- NCIT_C116745 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116745 NCIT_A7 NCIT_C26333 @default.
- NCIT_C116745 NCIT_NHC0 "C116745" @default.
- NCIT_C116745 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C116745 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116745 NCIT_P107 "Anti-Ly6E Antibody-Drug Conjugate RG 7841" @default.
- NCIT_C116745 NCIT_P108 "Anti-Ly6E Antibody-Drug Conjugate RG 7841" @default.
- NCIT_C116745 NCIT_P208 "CL473919" @default.
- NCIT_C116745 NCIT_P319 "ONS92I2A7F" @default.
- NCIT_C116745 NCIT_P322 "CTRP" @default.
- NCIT_C116745 NCIT_P322 "FDA" @default.
- NCIT_C116745 NCIT_P322 "GDC" @default.
- NCIT_C116745 NCIT_P329 "759448" @default.
- NCIT_C116745 NCIT_P330 "759448" @default.
- NCIT_C116745 NCIT_P375 "Anti-Ly6E Antibody-Drug Conjugate RG 7841" @default.
- NCIT_C116745 NCIT_P399 "759448" @default.
- NCIT_C116745 normalizedInformationContent "100" @default.
- NCIT_C116745 referenceCount "1" @default.
- NCIT_C116745 hasExactSynonym "ADC DLYE5953A" @default.
- NCIT_C116745 hasExactSynonym "Anti-LY6E-VCMMAE" @default.
- NCIT_C116745 hasExactSynonym "Anti-Ly6E Antibody-Drug Conjugate DLYE5953A" @default.
- NCIT_C116745 hasExactSynonym "Anti-Ly6E Antibody-Drug Conjugate RG 7841" @default.
- NCIT_C116745 hasExactSynonym "DLYE5953A" @default.
- NCIT_C116745 hasExactSynonym "RG 7841" @default.
- NCIT_C116745 hasExactSynonym "RG-7841" @default.
- NCIT_C116745 hasExactSynonym "RG7841" @default.
- NCIT_C116745 inSubset NCIT_C116977 @default.
- NCIT_C116745 inSubset NCIT_C116978 @default.
- NCIT_C116745 inSubset NCIT_C128784 @default.
- NCIT_C116745 inSubset NCIT_C157711 @default.
- NCIT_C116745 inSubset NCIT_C157712 @default.
- NCIT_C116745 inSubset NCIT_C176424 @default.
- NCIT_C116745 inSubset NCIT_C177537 @default.
- NCIT_C116745 inSubset NCIT_C63923 @default.
- NCIT_C116745 type Class @default.
- NCIT_C116745 isDefinedBy ncit.owl @default.
- NCIT_C116745 label "Anti-Ly6E Antibody-Drug Conjugate RG 7841" @default.
- NCIT_C116745 subClassOf NCIT_C116745 @default.
- NCIT_C116745 subClassOf NCIT_C129821 @default.
- NCIT_C116745 subClassOf NCIT_C129823 @default.
- NCIT_C116745 subClassOf NCIT_C1512 @default.
- NCIT_C116745 subClassOf NCIT_C1908 @default.
- NCIT_C116745 subClassOf NCIT_C1909 @default.
- NCIT_C116745 subClassOf NCIT_C274 @default.
- NCIT_C116745 subClassOf NCIT_C307 @default.
- NCIT_C116745 subClassOf NCIT_C308 @default.