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- NCIT_C116746 IAO_0000115 "An antibody-drug conjugate (ADC) composed of MMOT0530A, a humanized immunoglobulin (Ig) G1 monoclonal antibody directed against the cell surface glycoprotein mesothelin (MSLN), and covalently linked, via a protease-cleavable peptide linker, to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule disrupting agent, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of DMOT4039A binds to MSLN-expressing tumor cells and is internalized, thereby delivering MMAE intracellularly. Proteolytic cleavage releases MMAE, which then binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. MSLN, a tumor-associated antigen (TAA), is overexpressed by all mesotheliomas and a variety of other cancers, while it is minimally expressed in normal tissue." @default.
- NCIT_C116746 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116746 NCIT_A7 NCIT_C20887 @default.
- NCIT_C116746 NCIT_NHC0 "C116746" @default.
- NCIT_C116746 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116746 NCIT_P107 "Anti-mesothelin/MMAE Antibody-Drug Conjugate DMOT4039A" @default.
- NCIT_C116746 NCIT_P108 "Anti-mesothelin/MMAE Antibody-Drug Conjugate DMOT4039A" @default.
- NCIT_C116746 NCIT_P208 "CL433928" @default.
- NCIT_C116746 NCIT_P322 "CTRP" @default.
- NCIT_C116746 NCIT_P322 "GDC" @default.
- NCIT_C116746 NCIT_P329 "717527" @default.
- NCIT_C116746 NCIT_P330 "717527" @default.
- NCIT_C116746 NCIT_P375 "Anti-mesothelin/MMAE Antibody-Drug Conjugate DMOT4039A" @default.
- NCIT_C116746 NCIT_P399 "717527" @default.
- NCIT_C116746 normalizedInformationContent "100" @default.
- NCIT_C116746 referenceCount "1" @default.
- NCIT_C116746 hasExactSynonym "Anti-mesothelin/MMAE Antibody-Drug Conjugate DMOT4039A" @default.
- NCIT_C116746 hasExactSynonym "DMOT-4039A" @default.
- NCIT_C116746 hasExactSynonym "DMOT4039A" @default.
- NCIT_C116746 hasExactSynonym "RG 7600" @default.
- NCIT_C116746 hasExactSynonym "RG7600" @default.
- NCIT_C116746 inSubset NCIT_C116977 @default.
- NCIT_C116746 inSubset NCIT_C116978 @default.
- NCIT_C116746 inSubset NCIT_C128784 @default.
- NCIT_C116746 inSubset NCIT_C157711 @default.
- NCIT_C116746 inSubset NCIT_C157712 @default.
- NCIT_C116746 inSubset NCIT_C176424 @default.
- NCIT_C116746 inSubset NCIT_C177537 @default.
- NCIT_C116746 type Class @default.
- NCIT_C116746 isDefinedBy ncit.owl @default.
- NCIT_C116746 label "Anti-mesothelin/MMAE Antibody-Drug Conjugate DMOT4039A" @default.
- NCIT_C116746 subClassOf NCIT_C116746 @default.
- NCIT_C116746 subClassOf NCIT_C129821 @default.
- NCIT_C116746 subClassOf NCIT_C129823 @default.
- NCIT_C116746 subClassOf NCIT_C1512 @default.
- NCIT_C116746 subClassOf NCIT_C1908 @default.
- NCIT_C116746 subClassOf NCIT_C1909 @default.
- NCIT_C116746 subClassOf NCIT_C201535 @default.
- NCIT_C116746 subClassOf NCIT_C274 @default.
- NCIT_C116746 subClassOf NCIT_C307 @default.
- NCIT_C116746 subClassOf NCIT_C308 @default.
- NCIT_C116746 subClassOf NCIT_C575 @default.