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- NCIT_C116751 IAO_0000115 "An ophthalmic suspension containing the acetate form of fluorometholone, with potential anti-infective and immunosuppressive activities. Upon ocular administration, fluorometholone binds to glucocorticoid receptors in the cytoplasm and forms a receptor-ligand complex, which translocates to the nucleus where it binds to glucocorticoid response elements (GRE) in the promoter region of target genes. This leads to the expression of specific target genes that control inflammation. Specifically, by inducing the expression of lipocortins that inhibit the enzymatic activity of phospholipase A2, the release of arachidonic acid is blocked, which prevents the production of inflammatory mediators, and inflammatory-induced ocular swelling, redness and itching." @default.
- NCIT_C116751 NCIT_A7 NCIT_C17071 @default.
- NCIT_C116751 NCIT_NHC0 "C116751" @default.
- NCIT_C116751 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116751 NCIT_P107 "Fluorometholone Acetate Ophthalmic Suspension" @default.
- NCIT_C116751 NCIT_P108 "Fluorometholone Acetate Ophthalmic Suspension" @default.
- NCIT_C116751 NCIT_P207 "C1564840" @default.
- NCIT_C116751 NCIT_P322 "CTRP" @default.
- NCIT_C116751 NCIT_P329 "739978" @default.
- NCIT_C116751 NCIT_P330 "739978" @default.
- NCIT_C116751 NCIT_P399 "739978" @default.
- NCIT_C116751 NCIT_R122 NCIT_C16484 @default.
- NCIT_C116751 NCIT_R122 NCIT_C16486 @default.
- NCIT_C116751 NCIT_R122 NCIT_C16554 @default.
- NCIT_C116751 NCIT_R122 NCIT_C16865 @default.
- NCIT_C116751 NCIT_R122 NCIT_C16946 @default.
- NCIT_C116751 NCIT_R122 NCIT_C17021 @default.
- NCIT_C116751 NCIT_R122 NCIT_C17573 @default.
- NCIT_C116751 NCIT_R122 NCIT_C20027 @default.
- NCIT_C116751 NCIT_R122 NCIT_C26548 @default.
- NCIT_C116751 NCIT_R122 NCIT_C28459 @default.
- NCIT_C116751 normalizedInformationContent "100" @default.
- NCIT_C116751 referenceCount "1" @default.
- NCIT_C116751 hasExactSynonym "Fluorometholone Acetate Ophthalmic Suspension" @default.
- NCIT_C116751 inSubset NCIT_C116977 @default.
- NCIT_C116751 inSubset NCIT_C116978 @default.
- NCIT_C116751 inSubset NCIT_C176424 @default.
- NCIT_C116751 type Class @default.
- NCIT_C116751 isDefinedBy ncit.owl @default.
- NCIT_C116751 label "Fluorometholone Acetate Ophthalmic Suspension" @default.
- NCIT_C116751 subClassOf NCIT_C116751 @default.
- NCIT_C116751 subClassOf NCIT_C147908 @default.
- NCIT_C116751 subClassOf NCIT_C1636 @default.
- NCIT_C116751 subClassOf NCIT_C1908 @default.
- NCIT_C116751 subClassOf NCIT_C1909 @default.
- NCIT_C116751 subClassOf NCIT_C211 @default.
- NCIT_C116751 subClassOf NCIT_C2364 @default.
- NCIT_C116751 subClassOf NCIT_C308 @default.
- NCIT_C116751 subClassOf NCIT_C521 @default.
- NCIT_C116751 subClassOf NCIT_C548 @default.
- NCIT_C116751 subClassOf NCIT_C574 @default.