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- NCIT_C116756 IAO_0000115 "An orally bioavailable inhibitor of checkpoint kinase 1 (chk1), with potential antineoplastic and chemosensitization activities. Upon oral administration, chk1 inhibitor GDC-0425 selectively binds to chk1, thereby preventing activity of chk1 and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA, inhibition of cell cycle arrest, and induction of apoptosis. GDC-0425 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents. Chk1, an ATP-dependent serine/threonine kinase, mediates cell cycle checkpoint control, is essential for DNA repair, and plays a key role in resistance to chemotherapeutic agents." @default.
- NCIT_C116756 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116756 NCIT_A7 NCIT_C25919 @default.
- NCIT_C116756 NCIT_NHC0 "C116756" @default.
- NCIT_C116756 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116756 NCIT_P107 "Chk1 Inhibitor GDC-0425" @default.
- NCIT_C116756 NCIT_P108 "Chk1 Inhibitor GDC-0425" @default.
- NCIT_C116756 NCIT_P208 "CL433842" @default.
- NCIT_C116756 NCIT_P210 "1627539-18-7" @default.
- NCIT_C116756 NCIT_P319 "4N173XZ7SX" @default.
- NCIT_C116756 NCIT_P322 "CTRP" @default.
- NCIT_C116756 NCIT_P322 "FDA" @default.
- NCIT_C116756 NCIT_P322 "GDC" @default.
- NCIT_C116756 NCIT_P329 "701310" @default.
- NCIT_C116756 NCIT_P330 "701310" @default.
- NCIT_C116756 NCIT_P375 "Chk1 Inhibitor GDC-0425" @default.
- NCIT_C116756 NCIT_P399 "701310" @default.
- NCIT_C116756 normalizedInformationContent "100" @default.
- NCIT_C116756 referenceCount "1" @default.
- NCIT_C116756 hasExactSynonym "Chk1 Inhibitor GDC-0425" @default.
- NCIT_C116756 hasExactSynonym "GDC-0425" @default.
- NCIT_C116756 hasExactSynonym "RG7602" @default.
- NCIT_C116756 inSubset NCIT_C116977 @default.
- NCIT_C116756 inSubset NCIT_C116978 @default.
- NCIT_C116756 inSubset NCIT_C128784 @default.
- NCIT_C116756 inSubset NCIT_C157711 @default.
- NCIT_C116756 inSubset NCIT_C157712 @default.
- NCIT_C116756 inSubset NCIT_C176424 @default.
- NCIT_C116756 inSubset NCIT_C177537 @default.
- NCIT_C116756 inSubset NCIT_C63923 @default.
- NCIT_C116756 type Class @default.
- NCIT_C116756 isDefinedBy ncit.owl @default.
- NCIT_C116756 label "Chk1 Inhibitor GDC-0425" @default.
- NCIT_C116756 subClassOf NCIT_C116756 @default.
- NCIT_C116756 subClassOf NCIT_C129824 @default.
- NCIT_C116756 subClassOf NCIT_C129825 @default.
- NCIT_C116756 subClassOf NCIT_C1404 @default.
- NCIT_C116756 subClassOf NCIT_C155927 @default.
- NCIT_C116756 subClassOf NCIT_C1908 @default.
- NCIT_C116756 subClassOf NCIT_C1909 @default.
- NCIT_C116756 subClassOf NCIT_C2189 @default.
- NCIT_C116756 subClassOf NCIT_C274 @default.
- NCIT_C116756 subClassOf NCIT_C471 @default.
- NCIT_C116756 subClassOf NCIT_C61074 @default.