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- NCIT_C116777 IAO_0000115 "A cancer vaccine composed of a replication-deficient, attenuated derivative of the vaccinia virus strain Ankara expressing both a CD8+ T-cell epitope from the brachyury protein and a triad of T-cell co-stimulatory molecules (MVA Brachyury-TRICOM), with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration of the brachyury-expressing modified vaccinia Ankara (MVA)-TRICOM vaccine, the expressed brachyury protein induces specific CD8+ and CD4+ T-cell responses against brachyury-expressing tumor cells. This causes both tumor cell lysis and a decrease in the growth of brachyury-expressing tumor cells. Brachyury, a member of the T-box family of transcription factors that is overexpressed in numerous cancer cell types, is correlated with increased epithelial-mesenchymal transition (EMT), cancer resistance and cancer progression. TRICOM, a triad of three human T-cell co-stimulatory molecules, B7.1, ICAM-1 and LFA-3, enhances antigen-specific T-cell activation." @default.
- NCIT_C116777 NCIT_NHC0 "C116777" @default.
- NCIT_C116777 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116777 NCIT_P106 "Virus" @default.
- NCIT_C116777 NCIT_P108 "Brachyury-expressing Modified Vaccinia Ankara-TRICOM Vaccine" @default.
- NCIT_C116777 NCIT_P208 "CL473930" @default.
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- NCIT_C116777 hasExactSynonym "Brachyury-expressing Modified Vaccinia Ankara-TRICOM Vaccine" @default.
- NCIT_C116777 hasExactSynonym "MVA Brachyury-TRICOM" @default.
- NCIT_C116777 inSubset NCIT_C128784 @default.
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- NCIT_C116777 type Class @default.
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- NCIT_C116777 label "Brachyury-expressing Modified Vaccinia Ankara-TRICOM Vaccine" @default.
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