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- NCIT_C116788 IAO_0000115 "A fully human combinatorial antibody library (HuCAL)-derived monoclonal antibody targeting the B-cell-activating factor receptor (BAFF-R), with potential anti-inflammatory and antineoplastic activities. Upon administration, ianalumab targets and binds to BAFF-R, which inhibits both BAFF/BAFF-R interaction and BAFF-R-mediated signaling. This may decrease cell growth in tumor cells expressing BAFF-R. BAFF-R, also known as tumor necrosis factor receptor superfamily member 13C, is overexpressed in certain tumor cell types and autoimmune diseases. In cancer cells, BAFF-R plays a key role in B-cell proliferation and survival. VAY736 was developed using HuCAL technology." @default.
- NCIT_C116788 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116788 NCIT_NHC0 "C116788" @default.
- NCIT_C116788 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C116788 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116788 NCIT_P108 "Ianalumab" @default.
- NCIT_C116788 NCIT_P208 "CL473936" @default.
- NCIT_C116788 NCIT_P210 "1929549-92-7" @default.
- NCIT_C116788 NCIT_P319 "ZN2GQ3II96" @default.
- NCIT_C116788 NCIT_P322 "FDA" @default.
- NCIT_C116788 NCIT_P322 "GDC" @default.
- NCIT_C116788 NCIT_P329 "762784" @default.
- NCIT_C116788 NCIT_P330 "762784" @default.
- NCIT_C116788 NCIT_P375 "Human Combinatorial Antibody Library-based Monoclonal Antibody VAY736" @default.
- NCIT_C116788 NCIT_P375 "Ianalumab" @default.
- NCIT_C116788 NCIT_P399 "762784" @default.
- NCIT_C116788 NCIT_R124 NCIT_C17710 @default.
- NCIT_C116788 NCIT_R124 NCIT_C17828 @default.
- NCIT_C116788 NCIT_R124 NCIT_C18219 @default.
- NCIT_C116788 NCIT_R124 NCIT_C19986 @default.
- NCIT_C116788 NCIT_R124 NCIT_C40474 @default.
- NCIT_C116788 normalizedInformationContent "100" @default.
- NCIT_C116788 referenceCount "1" @default.
- NCIT_C116788 hasExactSynonym "HuCAL-based Antibody VAY736" @default.
- NCIT_C116788 hasExactSynonym "Human Combinatorial Antibody Library-based Monoclonal Antibody VAY736" @default.
- NCIT_C116788 hasExactSynonym "IANALUMAB" @default.
- NCIT_C116788 hasExactSynonym "Ianalumab" @default.
- NCIT_C116788 hasExactSynonym "VAY 736" @default.
- NCIT_C116788 hasExactSynonym "VAY736" @default.
- NCIT_C116788 inSubset NCIT_C128784 @default.
- NCIT_C116788 inSubset NCIT_C157711 @default.
- NCIT_C116788 inSubset NCIT_C157712 @default.
- NCIT_C116788 inSubset NCIT_C176424 @default.
- NCIT_C116788 inSubset NCIT_C177537 @default.
- NCIT_C116788 inSubset NCIT_C63923 @default.
- NCIT_C116788 type Class @default.
- NCIT_C116788 isDefinedBy ncit.owl @default.
- NCIT_C116788 label "Ianalumab" @default.
- NCIT_C116788 subClassOf NCIT_C116788 @default.
- NCIT_C116788 subClassOf NCIT_C129821 @default.
- NCIT_C116788 subClassOf NCIT_C129822 @default.
- NCIT_C116788 subClassOf NCIT_C1908 @default.
- NCIT_C116788 subClassOf NCIT_C1909 @default.
- NCIT_C116788 subClassOf NCIT_C20401 @default.
- NCIT_C116788 subClassOf NCIT_C274 @default.
- NCIT_C116788 subClassOf NCIT_C307 @default.
- NCIT_C116788 subClassOf NCIT_C308 @default.