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- NCIT_C116790 IAO_0000115 "A radiotracer composed of the bromide salt form of sepantronium, a small-molecule survivin antagonist and proapoptotic agent, labeled with the radionuclide carbon C 11, with potential positron emission tomography (PET) imaging activity. Upon administration, sepantronium is selectively taken up by tumor cells, binds to the survivin promoter and inhibits the transcription of survivin, which results in decreased survivin expression. Upon PET imaging, the tissue distribution of sepantronium and its tumor uptake can be assessed. Survivin, a member of the inhibitor of apoptosis (IAP) gene family, is overexpressed in a variety of human cancers; its expression in tumors is associated with a more aggressive phenotype, increased cancer cell proliferation, shorter survival times, and a decreased response to chemotherapy." @default.
- NCIT_C116790 NCIT_NHC0 "C116790" @default.
- NCIT_C116790 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116790 NCIT_P108 "Carbon C 11 Sepantronium Bromide" @default.
- NCIT_C116790 NCIT_P208 "CL473937" @default.
- NCIT_C116790 NCIT_P329 "762785" @default.
- NCIT_C116790 NCIT_P330 "762785" @default.
- NCIT_C116790 NCIT_P399 "762785" @default.
- NCIT_C116790 normalizedInformationContent "100" @default.
- NCIT_C116790 referenceCount "1" @default.
- NCIT_C116790 hasExactSynonym "11C-YM155" @default.
- NCIT_C116790 hasExactSynonym "Carbon C 11 Sepantronium Bromide" @default.
- NCIT_C116790 inSubset NCIT_C176424 @default.
- NCIT_C116790 type Class @default.
- NCIT_C116790 isDefinedBy ncit.owl @default.
- NCIT_C116790 label "Carbon C 11 Sepantronium Bromide" @default.
- NCIT_C116790 subClassOf NCIT_C116790 @default.
- NCIT_C116790 subClassOf NCIT_C1446 @default.
- NCIT_C116790 subClassOf NCIT_C1908 @default.
- NCIT_C116790 subClassOf NCIT_C1909 @default.
- NCIT_C116790 subClassOf NCIT_C2124 @default.