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- NCIT_C1168 IAO_0000115 "A synthetic bis-ethyl analogue of spermine with potential antineoplastic activity. N(1),N(11)-bis(ethyl)norspermine (DENSPM), a N-terminally alkylated tetraamine and polyamine mimetics, disrupts polyamine pool homeostasis by modulating the activities of the biosynthetic enzymes, ornithine decarboxylase (ODC), and S-adenosylmethionine decarboxylase (AdoMetDC). This agent also reduces polyamine concentrations through the induction of the catabolic enzyme spermidine/spermine N1-acetyltransferase 1 (SSAT). Polyamines, an integral part of the DNA helix structure, play a critical role in cell division, differentiation and membrane function. Disruption of normal polyamine concentrations by DENSPM may lead to cell growth inhibition." @default.
- NCIT_C1168 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1168 NCIT_NHC0 "C1168" @default.
- NCIT_C1168 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1168 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1168 NCIT_P108 "Diethylnorspermine" @default.
- NCIT_C1168 NCIT_P207 "C0067116" @default.
- NCIT_C1168 NCIT_P210 "121749-39-1" @default.
- NCIT_C1168 NCIT_P319 "HLI827Z1ST" @default.
- NCIT_C1168 NCIT_P322 "FDA" @default.
- NCIT_C1168 NCIT_P322 "GDC" @default.
- NCIT_C1168 NCIT_P329 "375649" @default.
- NCIT_C1168 NCIT_P330 "375649" @default.
- NCIT_C1168 NCIT_P366 "N_1_N_11_bis_ethyl_norspermine" @default.
- NCIT_C1168 NCIT_P375 "Diethylnorspermine" @default.
- NCIT_C1168 NCIT_P399 "375649" @default.
- NCIT_C1168 normalizedInformationContent "100" @default.
- NCIT_C1168 referenceCount "1" @default.
- NCIT_C1168 hasExactSynonym "CI-1006" @default.
- NCIT_C1168 hasExactSynonym "DENSPM" @default.
- NCIT_C1168 hasExactSynonym "DIETHYLNORSPERMINE" @default.
- NCIT_C1168 hasExactSynonym "Diethylnorspermine" @default.
- NCIT_C1168 hasExactSynonym "N(1),N(11)-diethylnorspermine" @default.
- NCIT_C1168 hasExactSynonym "N1,N11-bis(ethyl)norspermine" @default.
- NCIT_C1168 inSubset NCIT_C128784 @default.
- NCIT_C1168 inSubset NCIT_C157711 @default.
- NCIT_C1168 inSubset NCIT_C157712 @default.
- NCIT_C1168 inSubset NCIT_C176424 @default.
- NCIT_C1168 inSubset NCIT_C177537 @default.
- NCIT_C1168 inSubset NCIT_C63923 @default.
- NCIT_C1168 type Class @default.
- NCIT_C1168 isDefinedBy ncit.owl @default.
- NCIT_C1168 label "Diethylnorspermine" @default.
- NCIT_C1168 subClassOf NCIT_C1168 @default.
- NCIT_C1168 subClassOf NCIT_C186664 @default.
- NCIT_C1168 subClassOf NCIT_C1908 @default.
- NCIT_C1168 subClassOf NCIT_C1909 @default.
- NCIT_C1168 subClassOf NCIT_C274 @default.
- NCIT_C1168 subClassOf NCIT_C2842 @default.
- NCIT_C1168 subClassOf NCIT_C49109 @default.