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- NCIT_C116844 IAO_0000115 "An orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, fenebrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival." @default.
- NCIT_C116844 NCIT_A32 NCIT_C1909 @default.
- NCIT_C116844 NCIT_A7 NCIT_C75017 @default.
- NCIT_C116844 NCIT_NHC0 "C116844" @default.
- NCIT_C116844 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C116844 NCIT_P107 "Fenebrutinib" @default.
- NCIT_C116844 NCIT_P108 "Fenebrutinib" @default.
- NCIT_C116844 NCIT_P208 "CL774945" @default.
- NCIT_C116844 NCIT_P210 "1434048-34-6" @default.
- NCIT_C116844 NCIT_P319 "E9L2885WUL" @default.
- NCIT_C116844 NCIT_P322 "CTRP" @default.
- NCIT_C116844 NCIT_P322 "FDA" @default.
- NCIT_C116844 NCIT_P322 "GDC" @default.
- NCIT_C116844 NCIT_P329 "755178" @default.
- NCIT_C116844 NCIT_P330 "755178" @default.
- NCIT_C116844 NCIT_P375 "Fenebrutinib" @default.
- NCIT_C116844 NCIT_P399 "755178" @default.
- NCIT_C116844 normalizedInformationContent "100" @default.
- NCIT_C116844 referenceCount "1" @default.
- NCIT_C116844 hasExactSynonym "Bruton Tyrosine Kinase Inhibitor GDC-0853" @default.
- NCIT_C116844 hasExactSynonym "FENEBRUTINIB" @default.
- NCIT_C116844 hasExactSynonym "Fenebrutinib" @default.
- NCIT_C116844 hasExactSynonym "GDC-0853" @default.
- NCIT_C116844 inSubset NCIT_C116977 @default.
- NCIT_C116844 inSubset NCIT_C116978 @default.
- NCIT_C116844 inSubset NCIT_C128784 @default.
- NCIT_C116844 inSubset NCIT_C157711 @default.
- NCIT_C116844 inSubset NCIT_C157712 @default.
- NCIT_C116844 inSubset NCIT_C176424 @default.
- NCIT_C116844 inSubset NCIT_C177537 @default.
- NCIT_C116844 inSubset NCIT_C63923 @default.
- NCIT_C116844 type Class @default.
- NCIT_C116844 isDefinedBy ncit.owl @default.
- NCIT_C116844 label "Fenebrutinib" @default.
- NCIT_C116844 subClassOf NCIT_C116844 @default.
- NCIT_C116844 subClassOf NCIT_C124801 @default.
- NCIT_C116844 subClassOf NCIT_C129824 @default.
- NCIT_C116844 subClassOf NCIT_C129825 @default.
- NCIT_C116844 subClassOf NCIT_C1404 @default.
- NCIT_C116844 subClassOf NCIT_C163758 @default.
- NCIT_C116844 subClassOf NCIT_C163774 @default.
- NCIT_C116844 subClassOf NCIT_C1908 @default.
- NCIT_C116844 subClassOf NCIT_C1909 @default.
- NCIT_C116844 subClassOf NCIT_C1967 @default.
- NCIT_C116844 subClassOf NCIT_C2189 @default.
- NCIT_C116844 subClassOf NCIT_C274 @default.
- NCIT_C116844 subClassOf NCIT_C471 @default.